ArticleFrontiers in neuroscience2022
Functional Covariance Connectivity of Gray and White Matter in Olfactory-Related Brain Regions in Parkinson's Disease.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Brain Activities Responding to Acupuncture at ST36 (Frontiers in neurology · 2022Pooled it
- The olfactory-glymphatic syndrome: linking smell dysfunction, cognitive impairment and sleep disturbances in neuropathological disorders.Frontiers in neuroscience · 2026Review
- Amygdala subregion MRI alterations in Parkinson's disease correlate with olfactory function.Frontiers in aging neuroscience · 2026Article
- Olfactory network reorganization in Parkinson's disease.Parkinsonism & related disorders · 2025Article
- Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson's patients with hyposmia.NPJ systems biology and applications · 2025Article
- Altered white matter architecture in patients with isolated congenital anosmia.Brain structure & function · 2025Article
- White matter functional connectome gradient dysfunction in major depressive disorder.Psychoradiology · 2025Article
- Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study.Neuroradiology · 2024Article
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- Functional activity, functional connectivity and complex network biomarkers of progressive hyposmia Parkinson's disease with no cognitive impairment: evidences from resting-state fMRI study.Frontiers in aging neuroscience · 2024Article
- Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population.Frontiers in aging neuroscience · 2022Article
- Aberrant gray matter volume and functional connectivity in Parkinson's disease with minor hallucination.Frontiers in aging neuroscience · 2022Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Before the onset of motor symptoms, Parkinson's disease (PD) involves dysfunction of the anterior olfactory nucleus and olfactory bulb, causing olfactory disturbance, commonly resulting in hyposmia in the early stages of PD. Accumulating evidence has shown that blood oxygen level dependent (BOLD) signals in white matter are altered by olfactory disorders and related stimuli, and the signal changes in brain white matter pathways show a certain degree of specificity, which can reflect changes of early olfactory dysfunction in Parkinson's disease. In this study, we apply the functional covariance connectivity (FCC) method to decode FCC of gray and white matter in olfactory-related brain regions in Parkinson's disease. Our results show that the dorsolateral prefrontal, anterior entorhinal cortex and fronto-orbital cortices in the gray matter have abnormal connectivity with the posterior corona radiata and superior corona radiata in white matter in patients with Parkinson's hyposmia. The functional covariance connection strength (FCS) of the right dorsolateral prefrontal cortex and white matter, and the covariance connection strength of the left superior corona radiata and gray matter function have potential diagnostic value. These results demonstrate that alterations in FCC of gray and white matter in olfactory-related brain regions can reflect the change of olfactory function in the early stages of Parkinson's disease, indicating that it could be a potential neuroimaging marker for early diagnosis.
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