Evidence map›Paper›PMID 35310043›Full record

ArticleInternational journal of ophthalmology2022

Extracellular matrix gene expression in human trabecular meshwork cells following mechanical fluid flow stimulation.

Koichi Yoshida, Motofumi Kawai, Tsugiaki Utsunomiya, Akihiro Ishibazawa, Young-Seok Song, Mariana Sayuri B Udo, Yoshikazu Tasaki, Akitoshi Yoshida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Koichi YoshidaDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Motofumi KawaiDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Tsugiaki UtsunomiyaDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Akihiro IshibazawaDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Young-Seok SongDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Mariana Sayuri B UdoDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Yoshikazu TasakiDepartment of Hospital Pharmacy & Pharmacology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Akitoshi YoshidaDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Asahikawa Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate changes in extracellular matrix (ECM) gene expression in human trabecular meshwork (HTM) cells in response to mechanical fluid flow stimulation.

methodsHTM cells were grown on a glass plate coated with 0.02% type I collagen (COL) and exposed to shear stress (0, 0.2, 1.0 dyne/cm

resultsAfter mechanical stimulation, COL type 4 alpha 2, COL type 6 alpha 1, and fibronectin-1 mRNA were significantly higher than the static control (

conclusionChanges in the expressions of genes associated ECM metabolism result in HTM cells after mechanical stimulation. The mechanical stimulation of the aqueous humor to the trabecular meshwork may promote ECM turnover and contribute to intraocular pressure homeostasis.

Indexed as

aqueous humorextracellular matrixglaucomaintraocular pressureshear stresstrabecular meshwork

Identifiers

PMID35310043
PMCPMC8907041
OpenAlexW4214902815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.