ArticleFrontiers in bioengineering and biotechnology2022
Patient-Specific Cerebral Blood Flow Simulation Based on Commonly Available Clinical Datasets.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Personalized Computational Fluid Dynamics Analysis of Cerebral Venous Hemodynamics in a Case of Deep Cerebral Vein Thrombosis.Journal of personalized medicine · 2025Article
- Distinct Hemodynamic and Morphological Characteristics of Arteries Adjacent to White Matter Hyperintensities.CNS neuroscience & therapeutics · 2025Observational
- Personalised simulation of hemodynamics in cerebrovascular disease: lessons learned from a study of diagnostic accuracy.Frontiers in neurology · 2023Article
- Validation of a cerebral hemodynamic model with personalized calibration in patients with aneurysmal subarachnoid hemorrhage.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
Cerebral hemodynamics play an important role in the development of cerebrovascular diseases. In this work, we propose a numerical framework for modeling patient-specific cerebral blood flow, using commonly available clinical datasets. Our hemodynamic model was developed using Simscape Fluids library in Simulink, based on a block diagram language. Medical imaging data obtained from computerized tomography angiography (CTA) in 59 patients with aneurysmal subarachnoid hemorrhage was used to extract arterial geometry parameters. Flow information obtained from transcranial Doppler (TCD) measurement was employed to calibrate input parameters of the hemodynamic model. The results show that the proposed numerical model can reproduce blood flow in the circle of Willis (CoW) per patient per measurement set. The resistance at the distal end of each terminal branch was the predominant parameter for the flow distribution in the CoW. The proposed model may be a promising tool for assessing cerebral hemodynamics in patients with cerebrovascular disease.
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