Evidence map›Paper›PMID 35309887›Full record

SynthesisFrontiers in aging neuroscience2022

Effectiveness of Physical Activity Interventions on Cognition, Neuropsychiatric Symptoms, and Quality of Life of Alzheimer's Disease: An Update of a Systematic Review and Meta-Analysis.

Ya-Jing Liang, Qing-Wen Su, Zhi-Ren Sheng, Qiu-Yan Weng, Yan-Fang Niu, Hong-Di Zhou, Chun-Bo Liu

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Physical activity, neuropsychiatric symptoms, and physical function in nursing home residents: the HUNT 70+ study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya-Jing LiangDepartment of Nursing, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Qing-Wen SuDepartment of Health Management Center, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Zhi-Ren ShengDepartment of Nursing, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Qiu-Yan WengDepartment of Neurology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Yan-Fang NiuDepartment of Neurology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Hong-Di ZhouDepartment of Nursing, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Chun-Bo LiuDepartment of Nursing, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The topic of physical activity interventions for the treatment of Alzheimer's disease (AD) has been discussed for decades, but there are still inconsistent views on the effect of its intervention in different studies. With the increase in randomized controlled trials (RCTs), it is necessary to update newly published studies and systematically evaluate the effects of physical activity interventions. Scientific citation databases (e.g., PubMed, EMBASE, etc.) and registration databases (e.g., ISRCTN, CHICTR, etc.) were checked to screen RCTs and systematic reviews of physical activity interventions in AD. Then extract and review the intervention methods and their evaluation results in the included studies. Spearman correlation method was used to test the association between the mean difference (MD) of intervention results and activity time. The Hedges'g method was used to combine continuous data to analyze the standard MD (SMD) of different intervention types or time subgroups. The overall results show that physical activity intervention can improve the cognition, neuropsychiatric symptoms and quality of life (Qol) of AD patients, but the duration of the intervention significantly affected the outcome of the assessment. Subgroup analysis results showed that an intervention duration of 2-5 months had a significant advantage: cognitive function (Minimum Mental State Examination: SMD = 0.47, 95% CI = 0.33 ∼ 0.61,

Indexed as

Alzheimer’s diseasecognitionmeta-analysisneuropsychiatric symptomsphysical activityquality of lifesystematic review

Identifiers

PMID35309887
PMCPMC8926300

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.