Evidence map›Paper›PMID 35309731›Full record

ArticleOncoimmunology2022

QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment.

Kaspar Bresser, Meike E W Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers, Bjorn Siteur, Manon Boeije, Lona J Kroese, Ton N Schumacher

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Deciphering the role of CD47 in cancer immunotherapy.Journal of advanced research · 2024
    Review
  7. Review
  8. Combined Inhibition of the TGF-β1/Smad Pathway byInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Animals : an open access journal from MDPI · 2022
    Article
  11. Review
  12. Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kaspar BresserDivision of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0001-7113-0476
Meike E W LogtenbergDivision of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-8981-1189
Mireille ToebesDivision of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Natalie ProostPreclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Justin SprengersPreclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Bjorn SiteurPreclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Manon BoeijePreclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lona J KroeseTransgenic Facility, Mouse Clinic for Cancer and Aging Research, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
Ton N SchumacherDivision of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0003-0517-8804
The Netherlands Cancer Institute · NLLeiden University Medical Center · NL

Funding

European Research Council 742259
6 · The paper itself

Abstract

The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH

Indexed as

CD47 AntigenMelanomaAnimalsImmunotherapyMacrophagesMiceMonocytesTumor MicroenvironmentCD47 Antigencancer-associated fibroblastsgenetically modified mouse modelQPCTLtumor micro-environment

Identifiers

PMID35309731
PMCPMC8932921
OpenAlexW4220979495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.