Evidence map›Paper›PMID 35309480›Full record

ArticleACS omega2022

Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs.

Joseph D Morris, Leila Takahashi-Ruiz, Lauren N Persi, Jonathan C Summers, Erin P McCauley, Peter Y W Chan, Gabriella Amberchan, Itzel Lizama-Chamu, David A Coppage, Phillip Crews and 2 more

Abstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. 2,3-Dihydroquinazolin-4(1RSC medicinal chemistry · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joseph D MorrisDepartment of Natural Sciences, Dominican University of California, San Rafael, California 94901, United States.ORCID https://orcid.org/0000-0001-5218-425X
Leila Takahashi-RuizDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Lauren N PersiDepartment of Natural Sciences, Dominican University of California, San Rafael, California 94901, United States.
Jonathan C SummersDepartment of Natural Sciences, Dominican University of California, San Rafael, California 94901, United States.
Erin P McCauleyDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, California 95064, United States.
Peter Y W ChanDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.ORCID https://orcid.org/0000-0002-3498-6301
Gabriella AmberchanDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, California 95064, United States.ORCID https://orcid.org/0000-0001-7923-8385
Itzel Lizama-ChamuDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, California 95064, United States.
David A CoppageDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, California 95064, United States.
Phillip CrewsDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, California 95064, United States.ORCID https://orcid.org/0000-0002-9061-9549
April L RisingerDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.ORCID https://orcid.org/0000-0002-4363-3268
Tyler A JohnsonDepartment of Natural Sciences, Dominican University of California, San Rafael, California 94901, United States.ORCID https://orcid.org/0000-0001-6816-726X

Funding

NOVEL CYTOTOXIC NATURAL PRODUCTS FROM MARINE SPONGESR01CA047135 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CREWS, PHIL, VALERIOTE, FREDERICK AUGUSTUS · 1989 to 2017
$8.1M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NCI NIH HHS R01 CA047135NIH HHS S10 OD024998
6 · The paper itself

Abstract

Herein, we report on naturally derived microtubule stabilizers with activity against triple negative breast cancer (TNBC) cell lines, including paclitaxel, fijianolide B/laulimalide (

Identifiers

PMID35309480
PMCPMC8928504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.