Evidence map›Paper›PMID 35309405›Full record

ReviewHeliyon2022

Interactions of Glutamate and Gamma Amino Butyric Acid with the insulin-like growth factor system in traumatic brain injury (TBI) and/or cardiovascular accidents (CVA or stroke): A systematic review.

T I Morales, K A Stearns-Yoder, A S Hoffberg, T K Khan, H Wortzel, L A Brenner

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T I MoralesVA Rocky Mountain Mental Illness Research, Education and Clinical Center, University of Colorado, Anschutz School of Medicine, United States.
K A Stearns-YoderVA Rocky Mountain Mental Illness Research, Education and Clinical Center, University of Colorado, Anschutz School of Medicine, United States.
A S HoffbergVA Rocky Mountain Mental Illness Research, Education and Clinical Center, University of Colorado, Anschutz School of Medicine, United States.
T K KhanVA Rocky Mountain Mental Illness Research, Education and Clinical Center, University of Colorado, Anschutz School of Medicine, United States.
H WortzelVA Rocky Mountain Mental Illness Research, Education and Clinical Center, University of Colorado, Anschutz School of Medicine, United States.
L A BrennerVA Rocky Mountain Mental Illness Research, Education and Clinical Center, University of Colorado, Anschutz School of Medicine, United States.
University of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain maintains homeostasis of neural excitation in part through the receptor-mediated signaling of Glutamate (Glu) and Gamma Amino Butyric Acid (GABA), but localized injuries cause cellular release of excess Glu leading to neurotoxicity. The literature strongly supports the role of Insulin-like growth factor-1 (IGF-1) in adult brain neuroprotection and repair, and research supporting the existence of molecular interactions between Glu, GABA, and IGF-1

Indexed as

Brain ischemiaBrain neural excitationIGF binding proteinsIGF signalingNeuroprotectionNeurorepairTBI animal models

Identifiers

PMID35309405
PMCPMC8928062
OpenAlexW4214545989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.