Evidence map›Paper›PMID 35309318›Full record

ArticleFrontiers in immunology2022

Molecular Evolution of Transforming Growth Factor-β (TGF-β) Gene Family and the Functional Characterization of Lamprey TGF-β2.

Siqi Liu, Junfu Guo, Xianda Cheng, Wenna Li, Shuangyu Lyu, Xuanyi Chen, Qingwei Li, Hao Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Identification and Characterization of the Complete Genome of the TGF-International journal of molecular sciences · 2025
    Article
  6. Review
  7. Article
  8. Emerging role of BMPs/BMPR2 signaling pathway in treatment for pulmonary fibrosis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Review
  9. Comparative genomic studies on the TGF-β superfamily in blue whale.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Siqi LiuCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Junfu GuoCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Xianda ChengCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Wenna LiCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Shuangyu LyuCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Xuanyi ChenCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Qingwei LiCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Hao WangCollege of Life Sciences, Liaoning Normal University, Dalian, China.
Dalian Polytechnic University · CNLiaoning Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transforming growth factor-βs (TGF-βs) are multifunctional cytokines capable of regulating a wide range of cellular behaviors and play a key role in maintaining the homeostasis of the immune system. The TGF-β subfamily, which is only present in deuterostomes, expands from a single gene in invertebrates to multiple members in jawed vertebrates. However, the evolutionary processes of the TGF-β subfamily in vertebrates still lack sufficient elucidation. In this study, the TGF-β homologs are identified at the genome-wide level in the reissner lamprey (

Indexed as

PetromyzonTransforming Growth Factor beta2AnimalsEvolution, MolecularLipopolysaccharidesPhylogenyTransforming Growth FactorsVertebratesLipopolysaccharidesTransforming Growth Factor beta2Transforming Growth Factorscytokineimmune systemlampreyphylogenyTGF-β

Identifiers

PMID35309318
PMCPMC8931421
OpenAlexW4214815686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.