Evidence map›Paper›PMID 35309302›Full record

ArticleFrontiers in immunology2022

Rora Regulates Neutrophil Migration and Activation in Zebrafish.

Alan Y Hsu, Tianqi Wang, Ramizah Syahirah, Sheng Liu, Kailing Li, Weiwei Zhang, Jiao Wang, Ziming Cao, Simon Tian, Sandro Matosevic and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alan Y HsuDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Tianqi WangDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Ramizah SyahirahDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Sheng LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States.
Kailing LiCollaborative Core for Cancer Bioinformatics, Indiana University Simon Cancer Center, Indianapolis, IN, United States.
Weiwei ZhangDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Jiao WangDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, United States.
Ziming CaoDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Simon TianDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Sandro MatosevicDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, United States.
Christopher J StaigerDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Jun WanDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States.
Qing DengDepartment of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Purdue University West Lafayette · USIndiana University School of MedicineIndiana University – Purdue University Indianapolis · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Role of microRNAs in neutrophil migrationR35GM119787 · NIGMS · PURDUE UNIVERSITY · PI Qing Deng · 2016 to 2026
$4.9M
NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NIGMS NIH HHS R35 GM119787
6 · The paper itself

Abstract

Neutrophil migration and activation are essential for defense against pathogens. However, this process may also lead to collateral tissue injury. We used microRNA overexpression as a platform and discovered protein-coding genes that regulate neutrophil migration. Here we show that miR-99 decreased the chemotaxis of zebrafish neutrophils and human neutrophil-like cells. In zebrafish neutrophils, miR-99 directly targets the transcriptional factor

Indexed as

MicroRNAsZebrafishAnimalsCell MovementNeutrophilsZebrafish ProteinsMicroRNAsZebrafish Proteinschemotaxisinnate immunitymiR-99RAR-related orphan receptorzebrafish

Identifiers

PMID35309302
PMCPMC8931656
OpenAlexW4221024759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.