ArticleFrontiers in immunology2022
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19.
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Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
44 citing papers in PubMed, 53 citations in OpenAlex.
- Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.Science advances · 2023Trial
- Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.The Journal of clinical investigation · 2026Article
- SARS-CoV-2 Omicron variant spike protein maintains the ability to bind and activate human platelets: Comparison with the wild-type.Scientific reports · 2026Article
- Network Controllability Reveals Key Mitigation Points for Tumor-Promoting Signaling in Tumor-Educated Platelets.International journal of molecular sciences · 2025Article
- The Susceptibility Profiles of Human Peripheral Blood Cells toMicroorganisms · 2025Review
- Action of the Terminal Complement Pathway on Cell Membranes.The Journal of membrane biology · 2025Review
- Afucosylated IgG Promote Thrombosis in Mouse Injected with SARS-CoV-2 Spike Expressing Megakaryocytes.International journal of molecular sciences · 2025Article
- Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles.The Journal of clinical investigation · 2025Article
- Advances in our understanding of anti-PF4 related immunothrombosis.Frontiers in immunology · 2025Review
- The complement system in human pregnancy and preeclampsia.Frontiers in immunology · 2025Review
- Platelets as central hubs of inflammation.Frontiers in immunology · 2025Review
- Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report.American journal of respiratory cell and molecular biology · 2025Article
- Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval.Journal of Korean medical science · 2024Review
- Immune Characteristic Genes and Neutrophil Immune Transformation Studies in Severe COVID-19.Microorganisms · 2024Article
- Characterization of Large Immune Complexes with Size Exclusion Chromatography and Native Mass Spectrometry Supplemented with Gas Phase Ion Chemistry.Analytical chemistry · 2024Article
- The role of platelets in sepsis: A review.Biomolecules & biomedicine · 2024Review
- Does SARS-CoV-2 infect platelets?Frontiers in immunology · 2024Article
- Hemostasis-on-a-chip / incorporating the endothelium in microfluidic models of bleeding.Platelets · 2023Review
- Variant-derived SARS-CoV-2 spike protein does not directly cause platelet activation or hypercoagulability.Clinical and experimental medicine · 2023Article
Corrections and comments
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Authors and funding
37 authors at 4 institutions in 1 country.
Sokratis A ApostolidisInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Amrita SarkarDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Heather M GianniniDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Rishi R GoelInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Divij MathewInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Aae SuzukiDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
Amy E BaxterInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Allison R GreenplateInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Cécile AlanioInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Mohamed Abdel-HakeemInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Derek A OldridgeInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Josephine R GilesInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Jennifer E WuInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Zeyu ChenInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Yinghui Jane HuangInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Jonathan BelmanInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Ajinkya PattekarInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Sasikanth ManneInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Oliva KuthuruInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Jeanette DoughertyInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Brittany WeiderholdDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
Ariel R WeismanDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Caroline A G IttnerDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Sigrid GoumaDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Debora DunbarDivision of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Ian FrankDivision of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Alexander C HuangInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Laura A VellaInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
UPenn COVID Processing Unit
John P ReillyDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Scott E HensleyInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Lubica RauovaDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Liang ZhaoDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
Nuala J MeyerDivision of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Mortimer PonczDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Charles S AbramsDepartment of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
E John WherryInstitute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USTranslational Therapeutics (United States) · USParker Institute for Cancer Immunotherapy · US
Funding
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6MSubcellular Mechanisms pf Platelet ActivationP01HL040387 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JOEL S. · 1988 to 2018
$35.5MUniversity of Pennsylvania HIV Clinical Trials UnitUM1AI069534 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ian Frank, PABLO TEBAS · 2012 to 2026
$33.0MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MThrombosis Models CoreP01HL120846 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CHARLES S. · 2014 to 2018
$12.2MTRAINING IN PULMONARY IMMUNOLOGYT32HL007586 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 1985 to 2025
$8.8MNew Mechanistic Insights & Therapeutic Applications of Megakaryocytes/PlateletsR35HL150698 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Mortimer Poncz · 2020 to 2026
$7.3MTRANSFUSION MEDICINE RESEARCH TRAINING PROGRAMT32HL007775 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, DONALD LAWRENCE · 1993 to 2023
$2.8MTraining Program/Rheumatic DiseasesT32AR076951 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI EDWARD M BEHRENS, Peter A Merkel · 2020 to 2026
$2.6MTargeting Angiopoietin-2 in ARDSR01HL137006 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2017 to 2021
$2.5MReconsidering the IL-1 axis in sepsis-associated ARDSR01HL137915 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2017 to 2020
$2.1MCellular and transcriptional control of exhausted CD8 T cells lineage dynamicsR01AI105343 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2014 to 2017
$1.6MNCI NIH HHS F99 CA234842NCI NIH HHS K08 CA230157NCI NIH HHS T32 CA009140NHLBI NIH HHS P01 HL040387NHLBI NIH HHS P01 HL120846NHLBI NIH HHS R01 HL137006NHLBI NIH HHS R01 HL137915NHLBI NIH HHS R35 HL150698NHLBI NIH HHS R38 HL143613NHLBI NIH HHS T32 HL007586NHLBI NIH HHS T32 HL007775NIAID NIH HHS K08 AI136660NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI105343NIAID NIH HHS UM1 AI069534NIAMS NIH HHS T32 AR076951
Abstract
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflammation and pre-existing cardiovascular disease. Platelets are important mediators and sensors of inflammation and are directly affected by cardiovascular stressors. In this report, we found that platelets from severely ill, hospitalized COVID-19 patients exhibited higher basal levels of activation measured by P-selectin surface expression and had poor functional reserve upon
Indexed as
AdultAminopyridinesBlood PlateletsCells, CulturedComplement C5aCOVID-19FemaleHospitalizationHumansMaleMorpholinesPlatelet ActivationPyrimidinesReceptor, Anaphylatoxin C5aReceptors, IgGSARS-CoV-2AminopyridinesC5AR1 protein, humanComplement C5aFCGR2A protein, humanfostamatinibMorpholinesPyrimidinesReceptor, Anaphylatoxin C5aReceptors, IgGSyk KinasecomplementCOVID - 19FcγRIIafostamatinibplatelet
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