ArticleFrontiers in physiology2022
A New Method to Address the Importance of Detoxified Enzyme in Insecticide Resistance - Meta-Analysis.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Carvone-Rich Essential Oils and Their Agrobiological Interactions: A Review.Molecules (Basel, Switzerland) · 2026Review
- Spatial Heterogeneity ofJournal of parasitology research · 2026Review
- Acaricidal Activity and Potential Application ofInsects · 2025Article
- Resistance status ofNarra J · 2025Review
- Honey bee immune response to trace concentrations of clothianidin goes beyond the macronutrients found in artificial diets.Scientific reports · 2025Article
- Strong resistance to β-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis.Insect science · 2025Article
- Molecular analysis of acetylcholinesterase gene in field-collected populations of Musca domestica (Diptera: Muscidae) in Northwestern Iran.Journal of insect science (Online) · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Insect-borne diseases, such as malaria, and plant pathogens, like the tobacco mosaic virus, are responsible for human deaths and poor crop yields in communities around the world. The use of insecticides has been one of the major tools in pest control. However, the development of insecticide resistance has been a major problem in the control of insect pest populations that threaten the health of both humans and plants. The overexpression of detoxification genes is thought to be one of the major mechanisms through which pests develop resistance to insecticides. Hundreds of research papers have explored how overexpressed detoxification genes increase the resistance status of insects to an insecticide in recent years. This study is, for the first time, a synthesis of these resistance and gene expression data aimed at (1) setting up an example for the application of meta-analysis in the investigation of the mechanisms of insecticide resistance and (2) seeking to determine if the overexpression detoxification genes are responsible for insecticide resistance in insect pests in general. A strong correlation of increased levels of insecticide resistance has been observed in tested insects with cytochrome P450 (CYP), glutathione-S-transferase (GST), and esterase gene superfamilies, confirming that the overexpression of detoxification genes is indeed involved in the insecticide resistance through the increased metabolism of insecticides of insects, including medically (e.g., mosquito and housefly) and agriculturally (e.g., planthopper and caterpillar) important insects.
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