Evidence map›Paper›PMID 35308963›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2021

Multi-task deep learning-based survival analysis on the prognosis of late AMD using the longitudinal data in AREDS.

Gregory Ghahramani, Matthew Brendel, Mingquan Lin, Qingyu Chen, Tiarnan Keenan, Kun Chen, Emily Chew, Zhiyong Lu, Yifan Peng, Fei Wang

Open access · greenAbstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Gregory GhahramaniDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY USA.
Matthew BrendelDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY USA.
Mingquan LinDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.
Qingyu ChenNational Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH), Bethesda, MD USA.
Tiarnan KeenanNational Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD USA.
Kun ChenDepartment of Statistics, University of Connecticut, Storrs, CT USA.
Emily ChewNational Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD USA.
Zhiyong LuNational Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH), Bethesda, MD USA.
Yifan PengDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.
Fei WangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY USA.
Cornell University · USNational Institutes of Health · USNational Center for Biotechnology Information · USUniversity of Connecticut · USWeill Cornell Medicine · US

Funding

Developing Suicide Risk Algorithms for Diverse Clinical Settings using Data FusionR01MH124740 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ASELTINE, ROBERT H, CHEN, KUN · 2020 to 2023
$3.2M
Identification of Mild Cognitive Impairment using Machine Learning from Language and Behavior MarkersRF1AG072449 · NIA · MICHIGAN STATE UNIVERSITY · PI DODGE, HIROKO HAYAMA, WANG, FEI · 2021 to 2023
$2.6M
A framework to enhance radiology structured report by invoking NLP and DL: Models and ApplicationsR00LM013001 · NLM · WEILL MEDICAL COLL OF CORNELL UNIV · PI PENG, YIFAN · 2020 to 2022
$710k
NIA NIH HHS RF1 AG072449NIMH NIH HHS R01 MH124740NLM NIH HHS R00 LM013001
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of vision loss. Some patients experience vision loss over a delayed timeframe, others at a rapid pace. Physicians analyze time-of-visit fundus photographs to predict patient risk of developing late-AMD, the most severe form of AMD. Our study hypothesizes that 1) incorporating historical data improves predictive strength of developing late-AMD and 2) state-of-the-art deep-learning techniques extract more predictive image features than clinicians do. We incorporate longitudinal data from the Age-Related Eye Disease Studies and deep-learning extracted image features in survival settings to predict development of late- AMD. To extract image features, we used multi-task learning frameworks to train convolutional neural networks. Our findings show 1) incorporating longitudinal data improves prediction of late-AMD for clinical standard features, but only the current visit is informative when using complex features and 2) "deep-features" are more informative than clinician derived features. We make codes publicly available at https://github.com/bionlplab/AMD_prognosis_amia2021.

Indexed as

Deep LearningMacular DegenerationDisease ProgressionFundus OculiHumansPrognosisSurvival Analysis

Identifiers

PMID35308963
PMCPMC8861665
OpenAlexW4287399722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.