Evidence map›Paper›PMID 35308852›Full record

ArticleChemical science2022

Synthesis and evaluation of potent yaku'amide A analogs.

Concordia C L Lo, Daniel Joaquin, Diego A Moyá, Alexander Ramos, David W Kastner, Stephen M White, Blake L Christensen, Joseph G Naglich, William J Degnen, Steven L Castle

Abstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Concordia C L LoDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.
Daniel JoaquinDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.
Diego A MoyáDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.ORCID https://orcid.org/0000-0001-7694-1403
Alexander RamosDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.
David W KastnerDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.ORCID https://orcid.org/0000-0002-7766-4249
Stephen M WhiteDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.
Blake L ChristensenDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.ORCID https://orcid.org/0000-0001-5353-3976
Joseph G NaglichBristol Myers Squibb, Research & Early Development, Mechanistic Pharmacology-Leads Discovery & Optimization Rte 206 & Province Line Rd Princeton NJ 08543 USA.
William J DegnenSpectrix Analytical Services USA.
Steven L CastleDepartment of Chemistry and Biochemistry, Brigham Young University Provo UT 84602 USA scastle@chem.byu.edu.ORCID https://orcid.org/0000-0002-7837-4964

Funding

New Methods for Synthesizing Bioactive PeptidesR15GM114789 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI CASTLE, STEVEN L · 2016 to 2024
$1.4M
NIGMS NIH HHS R15 GM114789
6 · The paper itself

Abstract

Two full-length analogs of the anticancer peptide yaku'amide A (1a) and four partial structures have been synthesized. These analogs were identified by computational studies in which the three

Identifiers

PMID35308852
PMCPMC8848768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.