ArticleFrontiers in medicine2022
Tracheal Extubation Under Deep Anesthesia Using Transnasal Humidified Rapid Insufflation Ventilatory Exchange vs. Awake Extubation: An Open-Labeled Randomized Controlled Trial.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- A comparison of deep versus awake tracheal extubation in adults: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Propofol-assisted deep extubation in the dental treatment of pediatrics: a randomized controlled triple-blind trial.BMC anesthesiology · 2025Trial
- Deep extubation versus no-touch awake extubation in adults undergoing elective laparotomy: A randomised controlled trial.Indian journal of anaesthesia · 2026Article
- Response to: Comments on "Effects of immediate extubation in the operating room on long-term outcomes in living donor liver transplantation: a retrospective cohort study".Anesthesia and pain medicine · 2026Article
- Safety of propofol-assisted deep extubation in the dental treatment of children-a retrospective, observational study.BMC anesthesiology · 2024Observational
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tracheal extubation can be associated with several complications, including desaturation, agitation, hypertension, and tachycardia. We hypothesize that the use of transnasal humidified rapid insufflation ventilator exchange (THRIVE) immediately after extubation under deep anesthesia reduces the incidence of these adverse events. Methods: One hundred patients who underwent elective abdominal surgery under general anesthesia were randomly assigned to undergo tracheal extubation under deep anesthesia employing THRIVE (THRIVE group) or awake extubation (CONTROL group). The primary outcome was the incidence of experiencing desaturation (SpO Results: The THRIVE group showed a lower incidence of desaturation than the CONTROL group (12 vs. 54%, OR = 0.22 [95% CI, 0.10-0.49], Conclusion: Tracheal extubation under deep anesthesia using THRIVE decreases the incidence of desaturation and adverse haemodynamic events and increases patient satisfaction. Extubation under deep anesthesia using THRIVE might be an alternative strategy in selected patient populations.
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Registered trials
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