ReviewOxidative medicine and cellular longevity2022
A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases.
Review in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Metabolic profile association with white matter hyperintensity in patients with mild cognitive impairment.IBRO neuroscience reports · 2026Article
- Brain viral reservoir seeding and neurological metabolic dysregulation in early-life immunodeficiency virus infection.Brain pathology (Zurich, Switzerland) · 2026Article
- Protonophore uncouplers and the decoupler α,ω-hexadecanedioic acid relieve the succinate-induced blockade of glutamate and malate oxidation in the resting state (state 4).Journal of bioenergetics and biomembranes · 2026Article
- Proinflammatory state and metabolic dysregulation linking delayed feeding progression to extrauterine restricted head growth in extremely preterm infants.BMC medicine · 2025Article
- Viral reservoir seeding and neurological metabolic dysregulation in early-life immunodeficiency virus infection.Research square · 2025Article
- Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.Frontiers in veterinary science · 2025Article
- Beyond the Spectrum: Subtype-Specific Molecular Insights into Autism Spectrum Disorder Via Multimodal Data Integration.medRxiv : the preprint server for health sciences · 2024Article
- Bile acid modulation by gut microbiota: a bridge to understanding cognitive health.Annals of medicine and surgery (2012) · 2024Review
- Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2024Article
- Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024.Obesity pillars · 2024Article
- Hepatic interoception in health and disease.Autonomic neuroscience : basic & clinical · 2024Review
- Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injury.Cell reports. Medicine · 2024Article
- Bile acid profile associated with CSF and PET biomarkers in Alzheimer's disease.Aging clinical and experimental research · 2024Article
- Retracted: A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases.Oxidative medicine and cellular longevity · 2024Article
- Quantification of Bile Acids in Cerebrospinal Fluid: Results of an Observational Trial.Biomedicines · 2023Article
- Exploring the Intricate Nexus of Sarcopenia and Cognitive Impairment.Aging and disease · 2023Review
- Connecting the Gut Microbiota and Neurodegenerative Diseases: the Role of Bile Acids.Molecular neurobiology · 2023Review
- Bile Acids as Inducers of Protonophore and Ionophore Permeability of Biological and Artificial Membranes.Membranes · 2023Review
- The role of the gut microbiome and its metabolites in cerebrovascular diseases.Frontiers in microbiology · 2023Review
- Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis.Frontiers in endocrinology · 2023Review
Corrections and comments
- Retraction · 2024-01-09Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Investigation by Journal/Publisher · Investigation by Third Party · Paper Mill · Computer-Aided Content or Computer-Generated Content · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bile acids are commonly known as one of the vital metabolites derived from cholesterol. The role of bile acids in glycolipid metabolism and their mechanisms in liver and cholestatic diseases have been well studied. In addition, bile acids also serve as ligands of signal molecules such as FXR, TGR5, and S1PR2 to regulate some physiological processes in vivo. Recent studies have found that bile acids signaling may also play a critical role in the central nervous system. Evidence showed that some bile acids have exhibited neuroprotective effects in experimental animal models and clinical trials of many cognitive dysfunction-related diseases. Besides, alterations in bile acid metabolisms well as the expression of different bile acid receptors have been discovered as possible biomarkers for prognosis tools in multiple cognitive dysfunction-related diseases. This review summarizes biosynthesis and regulation of bile acids, receptor classification and characteristics, receptor agonists and signaling transduction, and recent findings in cognitive dysfunction-related diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.