Evidence map›Paper›PMID 35308082›Full record

ArticleBrain, behavior, & immunity - health2022

Peripheral inflammatory cytokines and motor symptoms in persons with Parkinson's disease.

K Diaz, M L Kohut, D W Russell, E L Stegemöller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  16. Differentiation and regulation of CD4Cellular and molecular life sciences : CMLS · 2024
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  20. The clinical characteristics of neuronal intranuclear inclusion disease and its relation with inflammation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

K DiazDepartment of Kinesiology, Iowa State University, Ames, IA, USA.
M L KohutDepartment of Kinesiology, Iowa State University, Ames, IA, USA.
D W RussellDepartment of Human Development & Family Studies, Iowa State University, Ames, IA, USA.
E L StegemöllerDepartment of Kinesiology, Iowa State University, Ames, IA, USA.
Iowa State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Many of the motor symptoms of Parkinson's disease (PD) impact quality of life and are not fully ameliorated by current pharmacological and surgical treatments. A better understanding of the pathophysiology underlying these symptoms is needed. Previous research has suggested that inflammation may play a significant role in PD pathophysiology and progression, but there is limited research exploring how inflammation directly relates to motor symptoms in PD. Thus, the purpose of this study was to evaluate associations between peripheral immune inflammatory markers and motor symptoms of PD, specifically, tremor, bradykinesia, and postural and gait instability. We hypothesized that peripheral inflammatory cytokines would predict the severity of motor symptoms in persons with PD, and that there will be higher levels of peripheral inflammatory cytokine markers in persons with PD when compared to age-matched healthy older adults. Methods: Twenty-six participants with PD and fourteen healthy older adults completed the study. For participants with PD, the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS) was recorded and scored by two Movement Disorders Neurologists masked to the study. A blood sample was collected from both participants with PD and the healthy older adults. Through the MILLIPLEX® map High Sensitivity Human Cytokine Kit, key inflammation-related markers were analyzed (TNF- Results: Results revealed significantly higher levels of IL-6 in persons with PD when compared to healthy older adults ( Conclusions: Overall, these results are consistent with a growing body of literature that implicates inflammatory cytokines in the PD, and further suggests that inflammatory cytokines, or lack thereof, may be associated with tremor in persons with PD.

Indexed as

BDI, Beck Depression InventoryIFNγ, Interferon gammaIL, interleukinsInflammatory cytokinesMDS-UPDRS, Movement Disorders Society Unified Parkinson's Disease Rating ScaleMMSE, Mini-Mental State ExamMotor impairmentsMovement Disorders Society Unified Parkinson's Disease Rating ScaleParkinson's diseasePD, Parkinson's diseasePeripheral inflammationTh cells, T helper cellsTNFα, Tumor necrosis factor-alpha

Identifiers

PMID35308082
PMCPMC8927904
OpenAlexW4221068851

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.