Evidence map›Paper›PMID 35308023›Full record

ArticleRSC medicinal chemistry2022

Structure-activity relationships of valine,

Eric Sparkes, Elizabeth A Cairns, Richard C Kevin, Felcia Lai, Katharina Elisabeth Grafinger, Shuli Chen, Marie H Deventer, Ross Ellison, Rochelle Boyd, Lewis J Martin and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. In vitro CBArchives of toxicology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 5 countries.

Eric SparkesSchool of Chemistry, The University of Sydney NSW 2006 Australia samuel.banister@sydney.edu.au.ORCID https://orcid.org/0000-0001-7296-9804
Elizabeth A CairnsThe Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney NSW 2050 Australia.ORCID https://orcid.org/0000-0002-9816-4761
Richard C KevinThe Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney NSW 2050 Australia.ORCID https://orcid.org/0000-0002-4912-4499
Felcia LaiSchool of Pharmacy, The University of Sydney NSW 2006 Australia.
Katharina Elisabeth GrafingerInstitute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg 79104 Freiburg Germany.ORCID https://orcid.org/0000-0002-3647-7455
Shuli ChenDepartment of Pharmacology and Toxicology, University of Otago Dunedin 9016 New Zealand.
Marie H DeventerLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University Ottergemsesteenweg 460 9000 Ghent Belgium.ORCID https://orcid.org/0000-0001-6667-2561
Ross EllisonClinical Toxicology and Environmental Biomonitoring Laboratory, University of California San Francisco CA 94143 USA.
Rochelle BoydSchool of Chemistry, The University of Sydney NSW 2006 Australia samuel.banister@sydney.edu.au.
Lewis J MartinThe Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney NSW 2050 Australia.ORCID https://orcid.org/0000-0002-8621-4258
Iain S McGregorThe Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney NSW 2050 Australia.
Roy R GeronaClinical Toxicology and Environmental Biomonitoring Laboratory, University of California San Francisco CA 94143 USA.
David E HibbsSchool of Pharmacy, The University of Sydney NSW 2006 Australia.ORCID https://orcid.org/0000-0002-2635-2990
Volker AuwärterInstitute of Forensic Medicine, Forensic Toxicology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg 79104 Freiburg Germany.
Michelle GlassDepartment of Pharmacology and Toxicology, University of Otago Dunedin 9016 New Zealand.
Christophe StoveLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University Ottergemsesteenweg 460 9000 Ghent Belgium.ORCID https://orcid.org/0000-0001-7126-348X
Samuel D BanisterSchool of Chemistry, The University of Sydney NSW 2006 Australia samuel.banister@sydney.edu.au.ORCID https://orcid.org/0000-0002-4690-4318
The University of Sydney · AUGhent University · BEUniversity of California, San Francisco · USUniversity of Freiburg · DEUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic cannabinoid receptor agonists (SCRAs) remain one the most prevalent classes of new psychoactive substances (NPS) worldwide, and examples are generally poorly characterised at the time of first detection. We have synthesised a systematic library of amino acid-derived indole-, indazole-, and 7-azaindole-3-carboxamides related to recently detected drugs ADB-BUTINACA, APP-BUTINACA and ADB-P7AICA, and characterised these ligands for

Identifiers

PMID35308023
PMCPMC8864554
OpenAlexW3211010213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.