SynthesisInternational ophthalmology2022
Efficacy of prophylactic laser retinopexy in acute retinal necrosis: A systematic review and meta-analysis.
Synthesis in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Acute Retinal Necrosis versus Progressive Outer Retinal Necrosis.Current ophthalmology reports · 2026Article
- Clinical characteristics and outcomes of acute retinal necrosis at different stages: a retrospective study.BMC ophthalmology · 2025Article
- Junctional proliferative vitreoretinopathy in rhegmatogenous retinal detachment secondary to viral retinitis in HIV.International ophthalmology · 2025Article
- Long-Term Functional Outcomes of Retinal Detachment Due to Acute Retinal Necrosis: A Case Series.Biomedicines · 2024Article
- Article
- Acute retinal necrosis in a patient with cervical malignant tumor treated with sintilimab: a case report and literature review.Frontiers in immunology · 2024Review
- Acute retinal necrosis: A mini review.Frontiers in ophthalmology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe performed a systematic review and meta-analysis to assess the role of prophylactic laser retinopexy in preventing rhegmatogenous retinal detachment (RRD) in acute retinal necrosis (ARN).
methodsPubmed, Embase and Cochrane databases were searched for eligible studies from inception to July 2020. Comprehensive clinical demographics were extracted from each study by two independent investigators. A random effects model was selected to analyze the OR of RRD risk and visual outcome with 95%CI. Subsequent subgroup and sensitivity analysis were conducted to evaluate the source of heterogeneity.
resultsA total of eight studies and 247 eyes (111 prophylactic laser retinopexy eyes and 136 eyes receiving antiviral treatment) were included in this analysis. There was moderate statistical heterogeneity across all studies. When compared with routine antiviral treatment alone, RRD risk decreased in patients receiving prophylactic laser retinopexy, however, this was not statistically significant (P = 0.09, OR = 0.42, 95%CI: 0.15-1.15). There was significant improvement in BCVA during the follow-up period in the prophylactic laser retinopexy subgroup (P = 0.01, WMD = - 0.98, 95%CI: - 1.74, - 0.22).
conclusionBased on current analysis, our results did not support convincing evidence of prophylactic laser in preventing RRD. Future studies featuring high-quality, multicenter trials will be required to correct baseline characteristics.
trial registrationThis meta-analysis has been retrospectively registered in Prospero (registration number: CRD42020201008).
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