ArticleScientific reports2022
Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Future Outlook Toward Heavy-Metal-Free Metal Chalcogenide Nanocrystals for Optoelectronic Applications.Small science · 2026Review
- Comparative pre- and post-treatment effects of aqueous Zingiber officinale Lsfunction in wistar rats: insights into NF-κB, Nrf2, and caspase-3 pathways.Journal of molecular histology · 2026Article
- BmATG5, BmATG6 and BmATG8 Are Involved in Autophagy and Apoptosis During Metamorphosis Induced by Cadmium inInternational journal of molecular sciences · 2026Article
- Cumulative Soil Metal Contamination Reshapes Oxidative and Neuroenzymatic Stress Responses in Ants Across an Industrial Pollution Gradient.Life (Basel, Switzerland) · 2026Article
- Sustained cadmium exposure and hyperglycemia additively drives mitochondrial dysfunction in hepatic cells: Implications for MASLD etiopathogenesis.Toxicology and applied pharmacology · 2026Article
- Perinatal exposure to metal mixtures disrupts neuronal function and behavior.Environmental research · 2026Article
- Influence of Cr and Cd accumulation and excretion on growth and gut microbiota in black soldier fly larvae (Diptera: Stratiomyidae).Frontiers in veterinary science · 2026Article
- Methods to Study DNA Damage Using Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Unravelling the Mechanism of N-Acetylcysteine in Alleviating Smoke-Induced Hypoxia-Driven Ocular Defects in Drosophila melanogaster.Molecular neurobiology · 2025Article
- Cadmium toxicity alleviation in rats using lactobacillus-fermented and unfermented opuntia ficus-indica L. juices.Toxicology reports · 2025Article
- Effects of ZnFeToxics · 2025Article
- Perinatal Exposure to Metal Mixtures Disrupts Neuronal Function and Behavior.bioRxiv : the preprint server for biology · 2025Article
- Review
- Neuroprotective Effects of Morin Against Cadmium- and Arsenic-Induced Cell Damage in PC12 Neurons.Biological trace element research · 2025Article
- Mechanistic insights into cadmium-related premature aging inFrontiers in neuroscience · 2025Article
- Plastic Fly: WhatInternational journal of molecular sciences · 2024Article
- Exposure to the Natural Compound Climacostol Induces Cell Damage and Oxidative Stress in the Fruit FlyToxics · 2024Article
- Biochemical and molecular assessment of oxidative stress in fruit fly exposed to azo dye Brilliant Black PN.Molecular biology reports · 2024Article
- An overview of the ameliorative efficacy ofFrontiers in public health · 2024Review
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the increase of human activities, cadmium (Cd) pollution has become a global environmental problem affecting biological metabolism in ecosystem. Cd has a very long half-life in humans and is excreted slowly in organs, which poses a serious threat to human health. In order to better understand the toxicity effects of cadmium, third instar larvae of Drosophila melanogaster (Canton-S strain) were exposed to different concentrations (1.125 mg/kg, 2.25 mg/kg, 4.5 mg/kg, and 9 mg/kg) of cadmium. Trypan blue staining showed that intestinal cell damage of Drosophila larvae increased and the comet assay indicated significantly more DNA damage in larvae exposed to high Cd concentrations. The nitroblue tetrazolium (NBT) experiments proved that content of reactive oxygen species (ROS) increased, which indicated Cd exposure could induce oxidative stress. In addition, the expression of mitochondrial adenine nucleotide transferase coding gene (sesB and Ant2) and apoptosis related genes (Debcl, hid, rpr, p53, Sce and Diap1) changed, which may lead to increased apoptosis. These findings confirmed the toxicity effects on oxidative stress and cell apoptosis in Drosophila larvae after early cadmium exposure, providing insights into understanding the effects of heavy metal stress in animal development.
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