ArticleVirologica Sinica2022
Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019.
Article in Virologica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 42 citations in OpenAlex.
- Novel recombinant human adenoviruses: A call for enhanced molecular surveillance, diagnosis, and management in pediatric acute respiratory infections.Pediatric investigation · 2026Article
- First detection of human adenovirus type 7 deletion mutant associated with an outbreak of acute respiratory infection.Virology journal · 2026Article
- Identification of Novel Recombinant Human Adenovirus Genotype B117 from Pediatric Cases, China.Emerging infectious diseases · 2026Article
- Antiviral Efficacy of the Traditional Chinese Medicine Mixture Yuanzhixingrenheji Against Human Adenovirus-7 In Vitro, In Vivo, and in a Clinical Retrospective Study.Pathogens (Basel, Switzerland) · 2026Article
- Long-Term Epidemiological Trends of Human Adenovirus Infection in South Korea: A Single-Center Study (2007-2024).Pathogens (Basel, Switzerland) · 2025Article
- Development and validation of a multi-platform LAMP system for rapid HAdV-3 and HAdV-7 detection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Clinical Characteristics of Adenovirus Pneumonia in Children.Pathogens (Basel, Switzerland) · 2025Article
- Post-COVID-19 resurgence of respiratory viruses in Taiwan: an interrupted time series analysis from three regional medical centers (2015-2023).BMC infectious diseases · 2025Article
- Identification of A Novel Human Adenovirus Type 114 Associated with An Acute Respiratory Disease Outbreak at An Elementary School - Beijing, China, September 2024.China CDC weekly · 2025Article
- Characterization of Human Viral Diversity and Adenovirus Isolates in a Sewage Treatment Plant in Tianjin: Implications for Public Health and Advanced Monitoring.Food and environmental virology · 2025Article
- Comparative analysis between genotypes of adenovirus isolates from hospitalized children with acute respiratory tract infections and clinical manifestations in Wuhan, China, from June 2022 to September 2023.Virologica Sinica · 2025Article
- Epidemiological, clinical, and molecular analysis of human adenovirus infections in hospitalized children with acute respiratory infections in Tianjin, China.Frontiers in cellular and infection microbiology · 2025Article
- Construction and validation of a mouse model for studying severe human adenovirus infections.Virologica Sinica · 2024Article
- Exploring the Efficacy of Peptides and Mimics against Influenza A Virus, Adenovirus, and Murine Norovirus.International journal of molecular sciences · 2024Article
- High-Frequency Recombination of Human Adenovirus in Children with Acute Respiratory Tract Infections in Beijing, China.Viruses · 2024Article
- Higher affinities of fibers with cell receptors increase the infection capacity and virulence of human adenovirus type 7 and type 55 compared to type 3.Microbiology spectrum · 2024Article
- Current antiviral agents against human adenoviruses associated with respiratory infections.Frontiers in pediatrics · 2024Review
- Adenovirus andFrontiers in pediatrics · 2024Article
- Genotypes and Phylogenetic Analysis of Human Adenovirus in Hospitalized Pneumonia and Influenza-Like Illness Patients in Jiangsu Province, China (2013-2021).Infection and drug resistance · 2024Article
- Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein.Frontiers in immunology · 2024Article
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12 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
During 2018-2019, a severe human adenovirus (HAdV) infection outbreak occurred in southern China. Here, we screened 18 respiratory pathogens in 1704 children (≤ 14 years old) hospitalized with acute respiratory illness in Guangzhou, China, in 2019. In total, 151 patients had positive HAdV test results; 34.4% (52/151) of them exhibited severe illness. HAdV infection occurred throughout the year, with a peak in summer. The median patient age was 3.0 (interquartile range: 1.1-5.0) years. Patients with severe HAdV infection exhibited increases in 12 clinical indexes (P ≤ 0.019) and decreases in four indexes (P ≤ 0.007), compared with patients exhibiting non-severe infection. No significant differences were found in age or sex distribution according to HAdV infection severity (P > 0.05); however, the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity (P < 0.05). The main epidemic types were HAdV-3 (47.0%, 71/151) and HAdV-7 (46.4%, 70/151). However, the severe illness rate was significantly higher in patients with HAdV-7 (51.4%) than in patients with HAdV-3 (19.7%) and other types of HAdV (20%) (P < 0.001). Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates. A representative HAdV-7 isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01 (accession no. DQ099432) (P > 0.05); the HAdV-7 isolate exhibited stronger virulence and infectivity, compared with HAdV-3 (P < 0.001). Overall, comorbid disease, HAdV co-infection, and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection; these data can facilitate treatment, control, and prevention of HAdV infection.
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