SynthesisBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Pooled it
- Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study.Brain connectivity · 2023Pooled it
- Stress-Related Brain Alterations in Chronic Pain.European journal of pain (London, England) · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders.Neuroscience applied · 2024Article
- Resolving Heterogeneity in Posttraumatic Stress Disorder Using Individualized Structural Covariance Network Analysis.Depression and anxiety · 2024Article
- Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder.Current psychiatry reports · 2023Review
- Brain patterns linked to neuropsychiatric genetic risk mirror those seen in disease.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
95 authors at 20 institutions in 9 countries.
Delin SunBrain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina.
Gopalkumar RakeshBrain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina.
Emily K Clarke-RubrightBrain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina.
Courtney C HaswellBrain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina.
Mark W LogueNational Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts; Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Erin N O'LearyDepartment of Psychiatry, University of Toledo, Toledo, Ohio.
Andrew S CottonDepartment of Psychiatry, University of Toledo, Toledo, Ohio.
Hong XieDepartment of Psychiatry, University of Toledo, Toledo, Ohio.
Emily L DennisPsychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, Massachusetts; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California; Stanford Neurodevelopment, Affect, and Psychopathology Laboratory, Stanford, California; Department of Neurology, University of Utah, Salt Lake City, Utah.
Neda JahanshadImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California.
Lauren E SalminenImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California.
Sophia I ThomopoulosImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California.
Faisal M RashidImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California.
Christopher R K ChingImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California.
Saskia B J KochDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands.
Jessie L FrijlingDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Laura NawijnDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Mirjam van ZuidenDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Xi ZhuDepartment of Psychiatry, Columbia University Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Benjamin Suarez-JimenezDepartment of Psychiatry, Columbia University Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York; University of Rochester Medical Center, Rochester, New York.
Anika SierkUniversity Medical Centre Charité, Berlin, Germany.
Henrik WalterUniversity Medical Centre Charité, Berlin, Germany.
Antje MantheyUniversity Medical Centre Charité, Berlin, Germany.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Murray B SteinDepartment of Psychiatry, University of California San Diego, San Diego, California.
Jessica BomyeaDepartment of Psychiatry, University of California San Diego, San Diego, California.
Inga KoertePsychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, Massachusetts; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.
Kyle ChoiHealth Services Research Center, University of California San Diego, San Diego, California.
Steven J A van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Robert R J M VermeirenDepartment of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.
Julia I HerzogDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Lauren A M LeboisDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Division of Depression and Anxiety Disorders, McLean Hospital, Harvard University, Belmont, Massachusetts.
Justin T BakerInstitute for Technology in Psychiatry, McLean Hospital, Harvard University, Belmont, Massachusetts.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Division of Depression and Anxiety Disorders, McLean Hospital, Harvard University, Belmont, Massachusetts; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Elizabeth A OlsonDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, Massachusetts.
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Mayuresh S KorgaonkarBrain Dynamics Centre, Westmead Institute of Medical Research, Westmead, New South Wales, Australia.
Elpiniki AndrewDepartment of Psychology, University of Sydney, Westmead, New South Wales, Australia.
Ye ZhuLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Gen LiLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Jonathan IpserSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Anna R HudsonDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Matthew PeverillDepartment of Psychology, University of Washington, Seattle, Washington.
Kelly SambrookDepartment of Radiology, University of Washington, Seattle, Washington.
Evan GordonVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas; Department of Psychology and Neuroscience, Baylor University, Waco, Texas; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas; Washington University School of Medicine, St. Louis, Missouri.
Lee A BaughDivision of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, South Dakota; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Sioux Falls VA Health Care System, Sioux Falls, South Dakota.
Gina ForsterDivision of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, South Dakota; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Brain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand.
Raluca M SimonsCenter for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Department of Psychology, University of South Dakota, Vermillion, South Dakota.
Jeffrey S SimonsCenter for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Department of Psychology, University of South Dakota, Vermillion, South Dakota.
Vincent A MagnottaDepartment of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, Iowa.
Adi Maron-KatzDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Stefan du PlessisDepartment of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Seth G DisnerMinneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
Nicholas D DavenportMinneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
Dan GrupeCenter for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin.
Jack B NitschkeDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin.
Terri A deRoon-CassiniDivision of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jacklynn FitzgeraldDepartment of Psychology, Marquette University, Milwaukee, Wisconsin.
John H KrystalDivision of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Ifat LevyDivision of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Miranda OlffDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; ARQ National Psychotrauma Centre, Diemen, the Netherlands.
Dick J VeltmanDepartment of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Li WangLaboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Yuval NeriaDepartment of Psychiatry, Columbia University Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Michael D De BellisHealthy Childhood Brain Development Developmental Traumatology Research Program, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina.
Tanja JovanovicDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, Michigan.
Judith K DanielsDepartment of Clinical Psychology, University of Groningen, Groningen, the Netherlands.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, Massachusetts; VA Boston Healthcare System, Brockton Division, Brockton, Massachusetts.
Nic J A van de WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Christian SchmahlDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Milissa L KaufmanDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Division of Women's Mental Health, McLean Hospital, Harvard University, Belmont, Massachusetts.
Isabelle M RossoDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, Massachusetts.
Scott R SponheimMinneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
David Bernd HofmannInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Richard A BryantSchool of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Kelene A FerchoDivision of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, South Dakota; Center for Brain and Behavior Research, University of South Dakota, Vermillion, South Dakota; Sioux Falls VA Health Care System, Sioux Falls, South Dakota; Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, Oklahoma.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Sven C MuellerDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium; Department of Personality, Psychological Assessment and Treatment, University of Deusto, Bilbao, Spain.
K Luan PhanDepartment of Psychiatry, University of Illinois at Chicago, Chicago, Illinois; Mental Health Service Line, Jesse Brown VA Chicago Health Care System, Chicago, Illinois.
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, Massachusetts.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin; Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin; Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin.
Christine LarsonDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Geoffrey MayVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas; Department of Psychology and Neuroscience, Baylor University, Waco, Texas; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, Texas.
Steven M NelsonVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas; Department of Psychology and Neuroscience, Baylor University, Waco, Texas; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, Texas.
Chadi G AbdallahDivision of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Hassaan GomaaDepartment of Psychiatry, Pennsylvania State University, State College, Pennsylvania.
Amit EtkinDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California; VA Palo Alto Health Care System, Palo Alto, California.
Soraya SeedatDepartment of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Ilan Harpaz-RotemDivision of Clinical Neuroscience, National Center for PTSD, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Israel LiberzonDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Xin WangDepartment of Psychiatry, University of Toledo, Toledo, Ohio.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California.
Rajendra A MoreyBrain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina. Electronic address: rajendra.morey@duke.edu.
Amsterdam UMC Location University of Amsterdam · NLImaging Center · USDuke University · USMcLean Hospital · USUniversity of South Dakota · USColumbia University Irving Medical Center · USUniversity of Toledo · USYale University · USBaylor University · USCharité - Universitätsmedizin Berlin · DEEmory University · USUniversity of Minnesota System · USUniversity of Wisconsin–Madison · USHarvard University · USHeidelberg University · DELeiden University · NLSouth African Medical Research Council · ZAStellenbosch University · ZAUniversity of California San Diego · USUniversity of Münster · DE
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MWISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2MX LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1MTRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6MNeurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MNCANDA Research Project Site: DukeU01AA021681 · NIAAA · DUKE UNIVERSITY · PI DAVID B. GOLDSTON · 2012 to 2026
$9.8MNeural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6MGenetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5MTrauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4MCSRD VA IK2 CX001600CSRD VA IK2 CX001680NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001863NCRR NIH HHS M01 RR000039NIAAA NIH HHS R01 AA012479NIAAA NIH HHS U01 AA021681NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS K12 HD085850NICHD NIH HHS P30 HD003352NICHD NIH HHS R01 HD071982NIDA NIH HHS K24 DA028773NIMH NIH HHS F32 MH101976NIMH NIH HHS F32 MH109274NIMH NIH HHS K01 MH092526NIMH NIH HHS K01 MH118428NIMH NIH HHS K01 MH118467NIMH NIH HHS K01 MH122774NIMH NIH HHS K23 MH101380NIMH NIH HHS K23 MH112873NIMH NIH HHS K24 MH071434NIMH NIH HHS L30 MH114379NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH061744NIMH NIH HHS R01 MH063407NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH105355NIMH NIH HHS R01 MH105535NIMH NIH HHS R01 MH106574NIMH NIH HHS R01 MH110483NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH113574NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH119227NIMH NIH HHS R01 MH129832NIMH NIH HHS R01 MH131532NIMH NIH HHS R21 MH098198NIMH NIH HHS R21 MH098212NIMH NIH HHS R21 MH102634NIMH NIH HHS R21 MH112956NIMH NIH HHS R21 MH125277NIMH NIH HHS R37 MH119194NIMH NIH HHS R56 MH071537NIMH NIH HHS T32 MH018931NINDS NIH HHS K99 NS096116RRD VA I01 RX000622RRD VA IK1 RX002325RRD VA IK2 RX000709RRD VA IK2 RX002922
Abstract
backgroundPosttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).
methodsNeuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2-148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks.
resultsPatients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks.
conclusionsCovariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD.
Indexed as
ConnectomeStress Disorders, Post-TraumaticAdolescentAdultAgedAged, 80 and overCase-Control StudiesChildHumansMagnetic Resonance ImagingMiddle AgedNeuroimagingYoung AdultBrain networkCortical thicknessDepressionPTSDStructural covarianceSurface area
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