Evidence map›Paper›PMID 35307353›Full record

ArticleThe Journal of biological chemistry2022

Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase-mediated inhibitory phosphorylation of the transcriptional coactivator YAP.

Louise Thines, Laëtitia Gorisse, Zhigang Li, Samar Sayedyahossein, David B Sacks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. CaCellular signalling · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Louise ThinesDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Laëtitia GorisseDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Zhigang LiDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Samar SayedyahosseinDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
David B SacksDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: sacksdb@mail.nih.gov.
National Institutes of Health · US

Funding

IQGAP1 in tumorigenesisZIACL080017 · CLC · CLINICAL CENTER · PI SACKS, DAVID · 2012 to 2025
$0k
6 · The paper itself

Abstract

The Hippo signaling pathway regulates tissue growth and cell fate, and its dysregulation can induce tumorigenesis. When Hippo is activated by cell-cell contact, extracellular signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibitory phosphorylation of the transcriptional coactivator Yes-associated protein (YAP) to maintain YAP in the cytoplasm or promote its degradation. Separately, calmodulin is a Ca

Indexed as

CalmodulinHippo Signaling PathwayAdaptor Proteins, Signal TransducingAnimalsCell ProliferationMammalsPhosphoproteinsPhosphorylationProtein Serine-Threonine KinasesTranscription FactorsAdaptor Proteins, Signal TransducingCalmodulinPhosphoproteinsProtein Serine-Threonine KinasesTranscription FactorscalmodulinHippo pathwaylarge tumor suppressor 1protein–protein interactionsignalingYes-associated protein

Identifiers

PMID35307353
PMCPMC9019248
OpenAlexW4220698810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.