Evidence map›Paper›PMID 35306870›Full record

ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2023

3D Photography to Quantify the Severity of Metopic Craniosynostosis.

Madeleine K Bruce, Wenzheng Tao, Justin Beiriger, Cameron Christensen, Miles J Pfaff, Ross Whitaker, Jesse A Goldstein

Abstract read
In one paragraph

Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Machine learning applications in craniosynostosis diagnosis and treatment prediction: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Pooled it
  2. Quantifying Sagittal Craniosynostosis Severity: A Machine Learning Approach With CranioRate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  3. Review
  4. Non-syndromic craniosynostosis.Nature reviews. Disease primers · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madeleine K BruceDepartment of Plastic Surgery, UPMC Children's Hospital, Pittsburgh, PA, United States.ORCID 0000-0002-4021-4551
Wenzheng TaoSchool of Computing, University of Utah, Salt Lake City, UT, United States.
Justin BeirigerDepartment of Plastic Surgery, UPMC Children's Hospital, Pittsburgh, PA, United States.
Cameron ChristensenSchool of Computing, University of Utah, Salt Lake City, UT, United States.
Miles J PfaffDepartment of Plastic Surgery, UPMC Children's Hospital, Pittsburgh, PA, United States.
Ross WhitakerSchool of Computing, University of Utah, Salt Lake City, UT, United States.
Jesse A GoldsteinDepartment of Plastic Surgery, UPMC Children's Hospital, Pittsburgh, PA, United States.ORCID 0000-0002-5242-3844

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R., MACLEOD, ROB S. · 2012 to 2019
$9.7M
Population-Based Shape and Biomechanical Analysis of Hip PathoanatomyR01EB016701 · NIBIB · UNIVERSITY OF UTAH · PI ANDERSON, ANDREW EDWARD · 2013 to 2023
$3.6M
ShapeWorks in the CloudR01AR076120 · NIAMS · UNIVERSITY OF UTAH · PI ELHABIAN, SHIREEN YOUSSEF · 2019 to 2024
$2.7M
New 3D and 4D Image-Based Clinical Measures of Atrial Structural and Functional Remodeling in Atrial FibrillationR01HL135568 · NHLBI · UNIVERSITY OF UTAH · PI CATES, JOSHUA E, ELHABIAN, SHIREEN YOUSSEF · 2017 to 2020
$1.4M
ShapeWorksStudio: An Integrative, User-Friendly, and Scalable Suite for Shape Representation and AnalysisU24EB029011 · NIBIB · UNIVERSITY OF UTAH · PI ELHABIAN, SHIREEN YOUSSEF · 2019 to 2023
$1.4M
Data-Driven Shape Analysis for Quantitative Severity Stratification in Patients with Metopic CraniosynostosisR21EB026061 · NIBIB · UNIVERSITY OF UTAH · PI GOLDSTEIN, JESSE AARON, WHITAKER, ROSS T · 2018 to 2019
$625k
NCATS NIH HHS UL1 TR001857NHLBI NIH HHS R01 HL135568NIAMS NIH HHS R01 AR076120NIBIB NIH HHS R01 EB016701NIBIB NIH HHS R21 EB026061NIBIB NIH HHS U24 EB029011NIGMS NIH HHS P41 GM103545
6 · The paper itself

Abstract

This study aims to determine the utility of 3D photography for evaluating the severity of metopic craniosynostosis (MCS) using a validated, supervised machine learning (ML) algorithm. This single-center retrospective cohort study included patients who were evaluated at our tertiary care center for MCS from 2016 to 2020 and underwent both head CT and 3D photography within a 2-month period. The analysis method builds on our previously established ML algorithm for evaluating MCS severity using skull shape from CT scans. In this study, we regress the model to analyze 3D photographs and correlate the severity scores from both imaging modalities. 14 patients met inclusion criteria, 64.3% male (n = 9). The mean age in years at 3D photography and CT imaging was 0.97 and 0.94, respectively. Ten patient images were obtained preoperatively, and 4 patients did not require surgery. The severity prediction of the ML algorithm correlates closely when comparing the 3D photographs to CT bone data (Spearman correlation coefficient [SCC] r = 0.75; Pearson correlation coefficient [PCC] r = 0.82). The results of this study show that 3D photography is a valid alternative to CT for evaluation of head shape in MCS. Its use will provide an objective, quantifiable means of assessing outcomes in a rigorous manner while decreasing radiation exposure in this patient population.

Indexed as

CraniosynostosesImaging, Three-DimensionalFemaleHumansInfantMalePhotographyRetrospective Studiesanatomycomputerized tomographycraniofacial morphologydysmorphologysynostosis

Identifiers

PMID35306870
PMCPMC9489814

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.