Evidence map›Paper›PMID 35306862›Full record

SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2022

Economic Evaluation of Early Psychosis Interventions From A Canadian Perspective.

Jean-Eric Tarride, Gord Blackhouse, Amal Abdel-Baki, Eric Latimer, Gillian Mulvale, Brian Cooper, Gord Langill, Deborah Milinkovic, Rosain Stennett, Jeremiah Hurley

Abstract readMeta-Analysis
In one paragraph

Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jean-Eric TarrideDepartment of Health Research Methods, Evidence, and Impact, 3710McMaster University, Hamilton, Ontario, Canada.
Gord BlackhouseDepartment of Health Research Methods, Evidence, and Impact, 3710McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-7157-6344
Amal Abdel-BakiDepartment of Psychiatry and Addiction, 5622Université de Montréal, Montreal, Quebec, Canada.ORCID 0000-0003-3333-9652
Eric LatimerMental Health and Society Division, Douglas Research Centre, Montreal, Quebec, Canada.
Gillian MulvaleCenter for Health Economics and Policy Analysis (CHEPA), 3710McMaster University, Hamilton, Ontario, Canada.
Brian CooperCleghorn Early Intervention Clinic, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Gord LangillCanadian Mental Health Association Haliburton Kawartha Pine Ridge Branch, Peterborough, Ontario, Canada.
Deborah MilinkovicCenter for Health Economics and Policy Analysis (CHEPA), 3710McMaster University, Hamilton, Ontario, Canada.
Rosain StennettDepartment of Health Research Methods, Evidence, and Impact, 3710McMaster University, Hamilton, Ontario, Canada.
Jeremiah HurleyCenter for Health Economics and Policy Analysis (CHEPA), 3710McMaster University, Hamilton, Ontario, Canada.

Funding

CIHR 156947
6 · The paper itself

Abstract

backgroundCompared to treatment as usual (TAU), early psychosis intervention programs (EPI) have been shown to reduce mortality, hospitalizations and days of assisted living while improving employment status.

aimsThe study aim was to conduct a cost-benefit analysis (CBA) and a cost-effectiveness analysis (CEA) to compare EPI and TAU in Canada.

methodsA decision-analytic model was used to estimate the 5-year costs and benefits of treating patients with a first episode of psychosis with EPI or TAU. EPI benefits were derived from randomized controlled trials (RCTs) and Canadian administrative data. The cost of EPI was based on a published survey of 52 EPI centers in Canada while hospitalizations, employment and days of assisted living were valued using Canadian unit costs. The outcomes of the CBA and CEA were expressed in terms of net benefit (NB) and incremental cost per life year gained (LYG), respectively. Scenario analyses were conducted to examine the impact of key assumptions. Costs are reported in 2019 Canadian dollars.

resultsBase case results indicated that EPI had a NB of $85,441 (95% CI: $41,140; $126,386) compared to TAU while the incremental cost per LYG was $26,366 (95% CI: EPI dominates TAU (less costs, more life years); $102,269). In all sensitivity analyses the NB of EPI remained positive and the incremental cost per LYG was less than $50,000.

conclusionsIn addition to EPI demonstrated clinical benefits, our results suggest that large-scale implementation of EPI in Canada would be desirable from an economic point of view .

Indexed as

Psychotic DisordersCanadaCost-Benefit AnalysisHumansQuality-Adjusted Life Yearscost-benefit analysisearly onset Schizophreniaeconomic analysispsychosis

Identifiers

PMID35306862
PMCPMC9510998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.