Evidence map›Paper›PMID 35306834›Full record

ArticleAntimicrobial agents and chemotherapy2022

Population Pharmacokinetic-Pharmacodynamic Target Attainment Analysis of Flomoxef in the Serum and Liver Tissue of Patients Undergoing Hepatic Resection.

Toshiaki Komatsu, Satomi Tsumuraya, Yoko Takayama, Takashi Kaizu, Mikiko Okamoto, Hiroshi Tajima, Nobuyuki Nishizawa, Hidefumi Kubo, Yusuke Kumamoto, Hirotsugu Okamoto and 2 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Toshiaki KomatsuDepartment of Pharmacy, Kitasato Universitygrid.410786.c Hospital, Kanagawa, Japan.ORCID 0000-0003-4196-0756
Satomi TsumurayaPharmacy Practice and Science I, Research and Education Center for Clinical Pharmacy, Kitasato Universitygrid.410786.c School of Pharmacy, Kanagawa, Japan.
Yoko TakayamaDepartment of Infection Control and Infectious Diseases, Research and Development, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Takashi KaizuDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Mikiko OkamotoDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Hiroshi TajimaDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Nobuyuki NishizawaDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Hidefumi KuboDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Yusuke KumamotoDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato Universitygrid.410786.c School of Medicine, Sagamihara, Japan.
Hirotsugu OkamotoDepartment of Anesthesiology, Kitasato Universitygrid.410786.c School of Medicine, Kanagawa, Japan.
Hideaki HanakiInfection Control Research Center, Kitasato Institute for Life Sciences, Kitasato Universitygrid.410786.c, Tokyo, Japan.
Koichiro AtsudaPharmacy Practice and Science I, Research and Education Center for Clinical Pharmacy, Kitasato Universitygrid.410786.c School of Pharmacy, Kanagawa, Japan.
Kitasato University · JPKitasato University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate the population pharmacokinetics of prophylactic flomoxef based on serum and liver tissue concentrations and to demonstrate a pharmacodynamic target concentration in the serum and liver tissue exceeding the MIC in order to design an effective dosing regimen. Serum samples (

Indexed as

Escherichia coliStaphylococcus aureusAnti-Bacterial AgentsCephalosporinsHumansLiverMethicillinMicrobial Sensitivity TestsAnti-Bacterial AgentsCephalosporinsflomoxefMethicillinflomoxefliver tissuepopulation pharmacokinetics

Identifiers

PMID35306834
PMCPMC9017303
OpenAlexW4220741025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.