Evidence map›Paper›PMID 35306582›Full record

ReviewArchives of gynecology and obstetrics2022

Which type of chromosomal mosaicism is compatible for embryo transfer: a systematical review and meta-analysis.

Yuanlin Ma, Lok-Wan Liu, Yongxiang Liu, Gaohui Shi, Xixiong Ai, Wenhui Hou, Qingyun Mai, Yanwen Xu

Abstract readReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Review in Archives of gynecology and obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuanlin Ma *Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Lok-Wan Liu *Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Yongxiang Liu *The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Gaohui ShiReproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Xixiong AiReproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Wenhui HouReproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Qingyun MaiReproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China.
Yanwen XuReproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sun University, ZhongshanEr Road No. 1, Yuexiu District, Guangzhou, 510080, Guangdong, China. xuyanwen@mail.sysu.edu.cn.ORCID 0000-0002-8308-9383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChromosomal mosaicism becomes a common phenomenon in Preimplantaion genetic testing (PGT). This meta-analysis was conducted to study which feature of chromosomal mosaicism was compatible for embryo transfer.

methodsAfter searching the database PubMed, Embase, CCTR and related reviews up until May 2021. Two reviewers extracted relevant information and assessed study quality by the Newcastle-Ottawa scale independently. Summary Odd Radios (OR) were calculated using fixed- or random-effects models for clinical outcomes. A network meta-analysis compared the clinical outcomes of different chromosomes.

resultsA total of six studies with 1,106 cycles of single mosaic embryo transferred were included. Significant results of implantation rate (IR), miscarriage rate (MR), and ongoing pregnancy/live birth rate (OP/LBR) were observed when comparing embryos with mosaicism level < 50% and ≥ 50% [OR 1.42, 95% CI (1.06, 1.89); OR 0.45, 95% CI (0.27, 0.75); OR 1.74, 95% CI (1.28, 2.37)], and embryos with mosaicism with only affecting segmental chromosome(s) and only involving whole chromosome(s) [OR 1.31, 95% CI (1.01, 1.71); OR 0.57, 95% CI (0.36, 0.93); OR 1.51, 95% CI (1.15, 2.00)]. Embryos with only mosaic gains or losses had significant higher IR and OP/LBR than complex mosaicism [Gains vs complex: OR 1.75, 95% CI (1.20, 2.54); OR 1.73, 95% CI (1.16, 2.58). Losses vs complex: OR 1.90, 95% CI (1.34, 2.71); OR 2.10, 95% CI (1.44, 3.07)]. Mosaic embryos with only one chromosome involved had significant favorable outcomes of IR and OP/LBR than with three or more chromosomes involved [OR 1.76, 95% CI (1.23, 2.52); OR 1.86, 95% CI (1.25,2.78)]. Chr. 7, Chr. 2, Chr. 1, Chr. 18, Chr. 11, Chr. X, Chr. 13, Chr. 14, Chr. 12, and Chr. 9 were considered as prioritized chromosomes of mosaic embryos for transfer.

conclusionsThis analysis support the embryos with mosaicism level ≥ 50%, whole chromosome(s) involved, multiple mosaic abnormalities were associated with worse pregnancy outcomes. Mosaicism level of 50% could be used as a threshold to assess the mosaic embryos.

Indexed as

Preimplantation DiagnosisAneuploidyBlastocystEmbryo TransferFemaleFertilization in VitroGenetic TestingHigh-Throughput Nucleotide SequencingHumansMosaicismPregnancyChromosomal mosaicismClinical outcomesIn vitro fertilizationNeonatal outcomesPreimplantation genetic testing for aneuploidy

Identifiers

PMID35306582

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.