ArticleSleep medicine2022
Enhancing cosinor analysis of circadian phase markers using the gamma distribution.
Article in Sleep medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap.Chest · 2026Guideline
- Oscillatory network efficiency predicts mood and fatigue during sleep deprivation.Communications biology · 2026Article
- The clinical value of circadian biofeedback in chronic heart failure.European heart journal. Digital health · 2026Article
- A SAS macro for multilevel Cosinor analysis.Computer methods and programs in biomedicine · 2026Article
- Article
- Predicting acute decompensated heart failure using circadian markers from heart rate time series.ESC heart failure · 2025Article
- Wearables in Chronomedicine and Interpretation of Circadian Health.Diagnostics (Basel, Switzerland) · 2025Review
- Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders.Scientific reports · 2024Article
- Using routinely collected clinical data for circadian medicine: A review of opportunities and challenges.PLOS digital health · 2024Review
- Approaches for assessing circadian rest-activity patterns using actigraphy in cohort and population-based studies.Current sleep medicine reports · 2023Article
- Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Circadian disruption and cancer- and treatment-related symptoms.Frontiers in oncology · 2022Review
- ANALYSIS OF PUBLIC INTEREST ABOUT OSTEOPOROSIS USING GOOGLE TRENDS: ARE SEASON AND ECONOMY EFFECTIVE?Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The cosinor model, in which a cosine curve is fitted to periodic data within a regression model, is a frequently used method for describing patterns of cyclical activity such as circadian rhythms. For circadian variables of interest (eg, melatonin and heart rate) that do not take on negative values, the assumption of normally distributed residuals required by the general linear model, which is most commonly used for cosinor analysis, may not be appropriate. Alternatively, a generalized linear model with the gamma distribution (GZLM-gamma) is specifically defined to accommodate non-negative outcomes. Herein, we demonstrate the improved fit and gains of efficiency in detection of circadian rhythm afforded by using the GZLM-gamma in cosinor models of heart rate, actigraphic activity, and urinary 6-sulfatoxymelatonin. Notably, this improved detection of circadian rhythm allows retention of additional patients for downstream analyses, further improving study power.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.