ArticleBiomedical journal2023
Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study.
Article in Biomedical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review.Developmental psychobiology · 2026Pooled it
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- Microbially derived glutathione from Eubacterium rectale alleviates oxidative stress and promotes intestinal epithelial recovery.Microbiome · 2026Article
- Gestational dysbiosis is associated with altered early-life microbial seeding and favors pathobiont expansion in offspring.iScience · 2026Article
- Gut-bone axis in rheumatoid arthritis: microbiota-driven barrier dysfunction, immune crosstalk, and therapeutic strategies.Antonie van Leeuwenhoek · 2026Review
- Clostridium Butyricum and Bifidobacterium Supplementation Ameliorates Gut Dysbiosis and Cognitive-Anxiety Behaviors in Preterm Mice.Probiotics and antimicrobial proteins · 2026Article
- Microbiome in heritage: how maternal microbiome transmission impacts next generation health.Microbiome · 2025Review
- Tea Catechins: Potential Plant-Derived Feed Additives for Improving Chicken Intestinal Health and Productivity.Animals : an open access journal from MDPI · 2025Article
- Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model.Frontiers in immunology · 2025Article
- Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers.Journal of animal science and biotechnology · 2024Review
- Bacillus CotA laccase improved the intestinal health, amino acid metabolism and hepatic metabolic capacity of Pekin ducks fed naturally contaminated AFBJournal of animal science and biotechnology · 2024Article
- Perturbed maternal microbiota shapes offspring microbiota during early colonization period in mice.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Article
- Gut bacteria-derived serotonin promotes immune tolerance in early life.Science immunology · 2024Article
- Article
- Transepithelial Barrier Dysfunction Drives Microbiota Dysbiosis to Initiate Epithelial Clock-driven Inflammation.Journal of Crohn's & colitis · 2023Article
- White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice.iScience · 2023Article
- Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice.Nutrients · 2023Article
- Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice.American journal of respiratory cell and molecular biology · 2023Article
- Recent Trends on Mitigative Effect of Probiotics on Oxidative-Stress-Induced Gut Dysfunction in Broilers under Necrotic Enteritis Challenge: A Review.Antioxidants (Basel, Switzerland) · 2023Review
- When it doesn't run in the blood(vessels) - events involved in vascular disorders.Biomedical journal · 2023Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the early postnatal life, gut microbiota development experiences dynamic changes in their structural and functional composition. The postnatal period is the critical window to develop a host defense mechanism. The maturation of intestinal mucosal barrier integrity is one of the essential defense mechanisms to prevent the entry of pathogens. However, the co-development of intestinal microbial colonization, formation of barrier integrity, and intestinal epithelial cell layer is not entirely understood.
methodsWe studied the gut microbial composition and diversity using 16S rRNA marker gene-based sequencing in mice to understand postnatal age-dependent association kinetics between gut microbial and intestinal development. Next, we assessed the intestinal development by in vivo gut permeability assay, mRNA gene expression of different tight junction proteins and intestinal epithelial cell markers, goblet cells population, villus length, and cecal IgA quantification.
resultsOur results showed a significant shift in gut microbial structural and functional composition from postnatal day 14 onwards with early life Proteobacteria abundance. Relative abundance of Verrucomicrobia was maximum at postnatal day 14 and showed a gradual decrease over time. We also observed an age-dependent biphasic pattern in barrier integrity improvement and differentiation of intestinal epithelial cells (IECs). A significant improvement in barrier integrity between days 1 and 7 showed the host factor contribution, while that beyond day 14 revealed an association with changes in microbiota composition. Our temporal correlation analysis associated Bacteroidetes phylum with the mucosal barrier formation during postnatal development.
conclusionsThe present study revealed the importance and interplay of host factors and the microbiome in gut development and intestinal mucosal homeostasis.
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