ArticleBiophysical journal2022
Sticking around: Cell adhesion patterning for energy minimization and substrate mechanosensing.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Modeling mechanochemical coupling in optogenetically activated cell layers.Biophysical journal · 2026Article
- napariTFM: An open-source tool for traction force microscopy and monolayer stress microscopy.PLoS computational biology · 2026Article
- Substrate stiffness modulates phenotype-dependent fibroblast contractility and migration independent of TGF-Mechanobiology in medicine · 2025Article
- Article
- Force propagation between epithelial cells depends on active coupling and mechano-structural polarization.eLife · 2023Article
- Cell size and actin architecture determine force generation in optogenetically activated cells.Biophysical journal · 2023Article
- Understanding How Cells Probe the World: A Preliminary Step towards Modeling Cell Behavior?International journal of molecular sciences · 2023Article
- Epithelial cells sense local stiffness via Piezo1 mediated cytoskeletal reorganization.Frontiers in cell and developmental biology · 2023Article
- Not just a number: What cells feel depends on how they grab it.Biophysical journal · 2022Article
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2 authors at 1 institution in 1 country.
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Abstract
Tissue stiffness (Young's modulus) is a key control parameter in cell behavior and bioengineered gels where defined mechanical properties have become an essential part of the toolkit for interrogating mechanotransduction. Here, we show using a mechanical cell model that the effective substrate stiffness experienced by a cell depends, not just on the engineered mechanical properties of the substrate but critically also on the particular arrangement of adhesions between cell and substrate. In particular, we find that cells with different adhesion patterns can experience two different gel stiffnesses as equivalent and will generate the same mean cell deformations. In considering small patches of adhesion, which mimic focal adhesion complexes, we show how the experimentally observed focal adhesion growth and elongation on stiff substrates can be explained by energy considerations. Relatedly, energy arguments also provide a reason why nascent adhesions do not establish into focal adhesions on soft substrates, as has been commonly observed. Fewer and larger adhesions are predicted to be preferred over more and smaller, an effect enhanced by random spot placing with the simulations predicting qualitatively realistic cell shapes in this case.
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