Evidence map›Paper›PMID 35305915›Full record

Observational studyArchives of cardiovascular diseases2022

Coronary artery calcifications and 6-month mortality in patients with COVID-19 without known atheromatous disease.

Anne-Sophie Le Hir, Antoine Fayol, Elie Mousseaux, Nicolas Danchin, Victoria Tea, Chekrallah Chamandi, Gilles Soulat, Etienne Puymirat

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Archives of cardiovascular diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Coronary artery calcification as a predictor of adverse outcomes in patients hospitalized with COVID-19.American heart journal plus : cardiology research and practice · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anne-Sophie Le HirFaculté de médecine, Sorbonne université, 75006 Paris, France.
Antoine FayolFaculté de médecine, université de Paris, 75006 Paris, France; Institut national de la santé et de la recherche médicale, PARCC, UMR970, 75015 Paris, France; CIC1418 and DMU CARTE, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France.
Elie MousseauxFaculté de médecine, université de Paris, 75006 Paris, France; Institut national de la santé et de la recherche médicale, PARCC, UMR970, 75015 Paris, France; Department of radiology, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France.
Nicolas DanchinFaculté de médecine, université de Paris, 75006 Paris, France; Department of cardiology, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France.
Victoria TeaFaculté de médecine, université de Paris, 75006 Paris, France; Institut national de la santé et de la recherche médicale, PARCC, UMR970, 75015 Paris, France.
Chekrallah ChamandiFaculté de médecine, université de Paris, 75006 Paris, France; Institut national de la santé et de la recherche médicale, PARCC, UMR970, 75015 Paris, France.
Gilles SoulatFaculté de médecine, université de Paris, 75006 Paris, France; Institut national de la santé et de la recherche médicale, PARCC, UMR970, 75015 Paris, France; Department of radiology, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France.
Etienne PuymiratFaculté de médecine, université de Paris, 75006 Paris, France; Institut national de la santé et de la recherche médicale, PARCC, UMR970, 75015 Paris, France; Department of cardiology, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France. Electronic address: etienne.puymirat@aphp.fr.
Université Paris Cité · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery calcium (CAC) is an independent risk factor for major adverse cardiovascular events; however, its impact on coronavirus disease 2019 (COVID-19) mortality remains unclear, especially in patients without known atheromatous disease.

aimsTo evaluate the association between CAC visual score and 6-month mortality in patients without history of atheromatous disease hospitalized with COVID-19 pneumonia.

methodsA single-centre observational cohort study was conducted, involving 293 consecutive patients with COVID-19 in Paris, France, between 13 March and 30 April 2020, with a 6-month follow-up. Patients with a history of ischaemic stroke or coronary or peripheral artery disease were excluded. The primary outcome was all-cause mortality at 6 months according to CAC score, which was assessed by analysing images obtained after the first routine non-electrocardiogram-gated computed tomography scan performed to detect COVID-19 pneumonia.

resultsA total of 251 patients (mean age 64.8±16.7 years) were included in the analysis. Fifty-one patients (20.3%) died within 6 months. The mortality rate increased with the magnitude of calcifications, and was 10/101 (9.9%), 15/66 (22.7%), 10/34 (29.4%) and 16/50 (32.0%) for the no CAC, mild CAC, moderate CAC and heavy CAC groups, respectively (p=0.004). Compared with the no calcification group, adjusted risk of death increased progressively with CAC: hazard ratio (HR) 2.37 (95% confidence interval [CI] 1.06-5.27), HR 3.1 (95% CI 1.29-7.45) and HR 4.02 (95% CI 1.82-8.88) in the mild, moderate and heavy CAC groups, respectively.

conclusionsNon-electrocardiogram-gated computed tomography during the initial pulmonary assessment of patients with COVID-19 without atherosclerotic cardiovascular disease showed a high prevalence of mild, moderate and heavy CAC. CAC score was related to 6-month mortality, independent of conventional cardiovascular risk factors. These results highlight the importance of CAC scoring for patients hospitalized with COVID-19, and calls for attention to patients with high CAC.

Indexed as

Brain IschemiaCoronary Artery DiseaseCOVID-19StrokeVascular CalcificationAgedAged, 80 and overCalciumCoronary AngiographyCoronary VesselsHumansMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsCalciumCoronaropathieCoronary artery diseaseCOVID-19Lésion myocardiqueMortalitéMortalityMyocardial injuryRisk stratificationStratification du risque

Identifiers

PMID35305915
PMCPMC8895715
OpenAlexW4214929184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.