Evidence map›Paper›PMID 35305880›Full record

ArticleNeuromuscular disorders : NMD2022

Simple and economical HandClench Relaxometer device for reliable and sensitive measurement of grip myotonia in myotonic dystrophy.

Thomas C Bulea, Amanda Guth, Nathan Sarkar, Andrew Gravunder, Bonnie Hodsdon, Kathleen Farrell, Leora E Comis, Rebecca Parks, Hirity Shimellis, Vanessa Ndege and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromuscular disorders : NMD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Thomas C BuleaFunctional and Applied Biomechanics Section, Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, United States of America. Electronic address: thomas.bulea@nih.gov.
Amanda GuthNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, United States of America.
Nathan SarkarNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, United States of America.
Andrew GravunderFunctional and Applied Biomechanics Section, Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, United States of America.
Bonnie HodsdonOccupational Therapy Section, Rehabilitation Medicine Department, NIH Clinical Center, Bethesda, MD, United States of America.
Kathleen FarrellOccupational Therapy Section, Rehabilitation Medicine Department, NIH Clinical Center, Bethesda, MD, United States of America.
Leora E ComisOccupational Therapy Section, Rehabilitation Medicine Department, NIH Clinical Center, Bethesda, MD, United States of America.
Rebecca ParksOccupational Therapy Section, Rehabilitation Medicine Department, NIH Clinical Center, Bethesda, MD, United States of America.
Hirity ShimellisNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, United States of America.
Vanessa NdegeNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, United States of America.
Pei-Shu HoEpidemiology and Biostatistics Section, Rehabilitation Medicine Department, NIH Clinical Center, Bethesda, MD, United States of America.
Ami MankodiNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, United States of America.
National Institutes of Health Clinical Center · USNational Institute of Neurological Disorders and Stroke · US

Funding

Hereditary Muscle Disease UnitZIANS003131 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MANKODI, AMI · 2012 to 2023
$11.7M
Intramural NIH HHS ZIA NS003131
6 · The paper itself

Abstract

Grip myotonia and weakness are attractive treatment response biomarkers in clinical trials of myotonic dystrophy type 1 (DM1). There is a need to develop simple, patient-friendly and reproducible methods of quantifying grip myotonia in multisite trial settings. We designed a HandClench Relaxometer (HCR) that measures grip myotonia and strength. In contrast with the existing quantitative myometry (QMA) setup, the HCR is portable, economical, can be used with any laptop and generates automated command prompts. We demonstrate the feasibility and reliability of HCR device in twenty DM1 individuals and ten age-matched controls; patients returned for follow up within two months. The device showed excellent day to day reproducibility (ICC >0.80) in patients. The HCR device detected myotonia in milder muscle disease and measured longer myotonia duration than QMA indicating enhanced sensitivity for quantifying myotonia in DM1. The reaction time to the relax but not squeeze command was delayed and showed warm up similar to myotonia in DM1. HCR outcomes were correlated with key pinch strength, hand dexterity test, and fat replacement in the MRI of the long finger flexor muscles. Use of the HCR is warranted for grip myotonia and strength measurements in longitudinal observational and interventional studies of DM1.

Indexed as

MyotoniaMyotonic DystrophyElectromyographyHand StrengthHumansInfantReproducibility of ResultsEquipmentEvaluation studyMyotoniaMyotonic dystrophyOutcome assessment

Identifiers

PMID35305880
PMCPMC12396005
OpenAlexW4213186371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.