Evidence map›Paper›PMID 35305692›Full record

ArticleEuropean journal of medical research2022

Mind the gap: IgG4-related disease mimicking infectious cerebral mass lesions.

Andrea De Maria, Chiara Sepulcri, Stefania Tutino, Federica Briano, Federica Toscanini, Pietro Fiaschi, Gianluigi Zona, Gabriele Gaggero, Matteo Bassetti

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Andrea De MariaClinica Malattie Infettive e Tropicali, DISSAL, University of Genoa, Largo R.Benzi 10, 16124, Genoa, Italy. De-maria@unige.it.ORCID http://orcid.org/0000-0001-5782-333X
Chiara SepulcriClinica Malattie Infettive e Tropicali, DISSAL, University of Genoa, Largo R.Benzi 10, 16124, Genoa, Italy.
Stefania TutinoClinica Malattie Infettive e Tropicali, DISSAL, University of Genoa, Largo R.Benzi 10, 16124, Genoa, Italy.
Federica BrianoClinica Malattie Infettive e Tropicali, DISSAL, University of Genoa, Largo R.Benzi 10, 16124, Genoa, Italy.
Federica ToscaniniDept. of Infectious Diseases, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Pietro FiaschiDept. of Neurosurgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Gianluigi ZonaDept. of Neurosurgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Gabriele GaggeroDept of Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Matteo BassettiClinica Malattie Infettive e Tropicali, DISSAL, University of Genoa, Largo R.Benzi 10, 16124, Genoa, Italy.
Ospedale Policlinico San Martino · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral intraparenchymal masses represent usually a neoplastic, or infectious differential diagnostic workup in neurology or infectious disease units. CASE PRESENTATION: Our patient was an 82-year-old male presenting with seizures, cerebral masses and a history of past treated pulmonary tuberculosis. Initial workup included a differential diagnosis of an infectious mass/multiple abscess. After exclusion of infectious or primary neoplastic origins by negative HIV serology, the absence of immune suppression, endocarditic lesions, negative results of blood cultures and bronchoalveolar lavage, negative cerebrospinal fluid workout on spinal tap led to exclusion of infectious causes. A surgical procedure was performed to access one of the lesions. This yielded a firm, cyst-like mass of histiocytic granulomatous tissue with a conspicuous plasmacellular component and a relevant IgG4 plasmacellular component consistent with IgG4-related disease. Steroid treatment determined conspicuous improvement and led to discharge of the patient.

conclusionParenchymal IgG4-related disease may be included as a new entity in the differential diagnosis of single or multiple cerebral masses in addition to infectious or neoplastic etiology.

Indexed as

Diagnosis, DifferentialAgedBrain NeoplasmsHumansImmunoglobulin G4-Related DiseaseMaleParenchymal TissueAbscessCerebralCNS massIgG4IgG4-related diseaseMRI

Identifiers

PMID35305692
PMCPMC8933968
OpenAlexW4220701061

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.