Evidence map›Paper›PMID 35305685›Full record

ArticleActa neuropathologica communications2022

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease.

Catarina Oliveira Miranda, Rui Jorge Nobre, Vitor Hugo Paiva, João Valente Duarte, João Castelhano, Lorena Itatí Petrella, José Sereno, Magda Santana, Sónia Afonso, Cristina Januário and 2 more

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Catarina Oliveira Miranda *Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC), Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal. csmiranda@cnc.uc.pt.ORCID 0000-0001-5241-8108
Rui Jorge Nobre *Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC), Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal. rui.nobre@cnc.uc.pt.ORCID 0000-0001-5816-2051
Vitor Hugo PaivaInstitute for Interdisciplinary Research (III), UC, Casa Costa Alemão - Pólo II, Rua Dom Francisco de Lemos, 3030-789, Coimbra, Portugal.
João Valente DuarteCenter for Innovative Biomedicine and Biotechnology (CIBB), Faculdade de Medicina, UC, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal.
João CastelhanoCenter for Innovative Biomedicine and Biotechnology (CIBB), Faculdade de Medicina, UC, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal.
Lorena Itatí PetrellaCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), UC, Edifício Do ICNAS, Polo 3, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
José SerenoCenter for Innovative Biomedicine and Biotechnology (CIBB), Faculdade de Medicina, UC, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal.
Magda SantanaCenter for Neuroscience and Cell Biology (CNC), University of Coimbra (UC), Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal.
Sónia AfonsoCenter for Innovative Biomedicine and Biotechnology (CIBB), Faculdade de Medicina, UC, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal.
Cristina JanuárioCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), UC, Edifício Do ICNAS, Polo 3, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Miguel Castelo-Branco *Center for Innovative Biomedicine and Biotechnology (CIBB), Faculdade de Medicina, UC, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal.
Luís Pereira de Almeida *Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC), Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Portugal. luispa@cnc.uc.pt.ORCID 0000-0001-5831-3307
Association for Innovation and Biomedical Research on Light and Image · PTUniversity of Coimbra · PTHospitais da Universidade de Coimbra · PTInstitute for Systems Engineering and Computers · PTInstitute of Marine Research · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (

Indexed as

Machado-Joseph DiseaseAnimalsBiomarkersCerebellumGlutamic AcidHumansMiceMice, TransgenicTaurineBiomarkersGlutamic AcidTaurineMachado-Joseph disease (MJD)Magnetic resonance imaging (MRI)Motor performanceProton magnetic resonance spectroscopy (1H-MRS) biomarkersSpinocerebellar ataxia type 3 (SCA3)

Identifiers

PMID35305685
PMCPMC8933766
OpenAlexW4220716443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.