Evidence map›Paper›PMID 35305667›Full record

Trial reportMalaria journal2022

Durability of three types of dual active ingredient long-lasting insecticidal net compared to a pyrethroid-only LLIN in Tanzania: methodology for a prospective cohort study nested in a cluster randomized controlled trial.

Jackline L Martin, Louisa A Messenger, Franklin W Mosha, Eliud Lukole, Jacklin F Mosha, Manisha Kulkarni, Thomas S Churcher, Ellie Sherrard-Smith, Alphaxard Manjurano, Natacha Protopopoff and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03554616 (Efficacy of Three Different Bi-treated Long Lasting Insecticidal Nets and Deployment Strategy for Control of Malaria Transmitted by Pyrethroid Resistant Vectors), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03554616 nacompletednot on this map

Efficacy of Three Different Bi-treated Long Lasting Insecticidal Nets and Deployment Strategy for Control of Malaria Transmitted by Pyrethroid Resistant Vectors: A Randomised Controlled Trial

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2019 to 2023Enrolled4,200ConditionsMalaria, AnaemiaArmsChlorfenapyr LLIN, pyriproxyfen LLIN, Piperonyl butoxide LLIN, Standard LLIN
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Jackline L MartinKilimanjaro Christian Medical University College, Moshi, United Republic of Tanzania. Jackline.martin@lshtm.ac.uk.
Louisa A MessengerLondon School of Hygiene and Tropical, London, UK.
Franklin W MoshaKilimanjaro Christian Medical University College, Moshi, United Republic of Tanzania.
Eliud LukoleNational Institute for Medical Research-Mwanza Center, Mwanza, United Republic of Tanzania.
Jacklin F MoshaNational Institute for Medical Research-Mwanza Center, Mwanza, United Republic of Tanzania.
Manisha KulkarniUniversity of Ottawa, Ottawa, Canada.
Thomas S ChurcherImperial College, London, UK.
Ellie Sherrard-SmithImperial College, London, UK.
Alphaxard ManjuranoNational Institute for Medical Research-Mwanza Center, Mwanza, United Republic of Tanzania.
Natacha Protopopoff *London School of Hygiene and Tropical, London, UK.
Mark Rowland *London School of Hygiene and Tropical, London, UK.
London School of Hygiene & Tropical Medicine · GBNational Institute for Medical Research · TZImperial College London · GBKilimanjaro Christian Medical Centre · TZUniversity of Ottawa · CA

Funding

Medical Research Council MR/R006040/1Medical Research Council MR/R015600/1Medical Research Council MR/T041986/1
6 · The paper itself

Abstract

backgroundProgress achieved by long-lasting insecticidal nets (LLINs) against malaria is threatened by widespread selection of pyrethroid resistance among vector populations. LLINs with non-pyrethroid insecticides are urgently needed. This study aims to assess the insecticide and textile durability of three classes of dual-active ingredient (A.I.) LLINs using techniques derived from established WHO LLIN testing methods to set new standards of evaluation.

methodsA WHO Phase 3 active ingredients and textile durability study will be carried out within a cluster randomized controlled trial in 40 clusters in Misungwi district, Tanzania. The following treatments will be evaluated: (1) Interceptor

conclusionsStudy findings will help develop bio-efficacy and physical durability criteria for partner A.I., in relation to the cRCT epidemiological and entomological outcomes, and refine preferred product characteristics of each class of LLIN. If suitable, the bioassay and hut outcomes will be fitted to transmission models to estimate correlation with cRCT outcomes. TRIAL REGISTRATION NUMBER: NCT03554616.

Indexed as

InsecticidesInsecticide-Treated BednetsPyrethrinsFemaleHumansMosquito ControlMosquito VectorsProspective StudiesTanzaniaInsecticidesPyrethrinsBio-efficacyChlorfenapyrExperimental hut trialInsecticide resistanceInterceptorInterceptor G2Long-lasting insecticidal netMalaria vectorsOlyset plusPiperonyl butoxidePyriproxyfenRoyal GuardTanzaniaTextile durability

Identifiers

PMID35305667
PMCPMC8934498
OpenAlexW4220798559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.