Evidence map›Paper›PMID 35305646›Full record

ArticleBMC veterinary research2022

Toxoplasma gondii is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: a prospective cohort study.

Thomas Clune, Amy Lockwood, Serina Hancock, Andrew N Thompson, Mieghan Bruce, Sue Beetson, Angus J Campbell, Elsa Glanville, Daniel Brookes, Colin Trengove and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Seroprevalence of Specific Antibodies toAnimals : an open access journal from MDPI · 2022
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  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Thomas CluneCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
Amy LockwoodCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
Serina HancockCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
Andrew N ThompsonCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
Mieghan BruceCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
Sue BeetsonCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
Angus J CampbellNossal Institute for Global Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, 3010, Australia.
Elsa GlanvilleMackinnon Project, Faculty of Veterinary & Agricultural Sciences, University of Melbourne, Werribee, Victoria, 3030, Australia.
Daniel BrookesMackinnon Project, Faculty of Veterinary & Agricultural Sciences, University of Melbourne, Werribee, Victoria, 3030, Australia.
Colin TrengoveSchool of Animal and Veterinary Science, University of Adelaide, Roseworthy, South Australia, 5371, Australia.
Ryan O'HandleySchool of Animal and Veterinary Science, University of Adelaide, Roseworthy, South Australia, 5371, Australia.
Caroline JacobsonCentre for Animal Production and Health, Food Futures Institute, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia. C.Jacobson@murdoch.edu.au.
Murdoch University · AUUniversity of Adelaide · AUUniversity of Melbourne · AUThe George Institute for Global Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundToxoplasma gondii causes reproductive losses in sheep worldwide, including Australia. The reproductive performance of primiparous ewes is typically lower than for mature, multiparous ewes, and younger ewes are more likely to be immunologically naïve and therefore more susceptible to reproductive disease if T. gondii infection occurs during pregnancy. The aim of this study was to assess the impact of infection with T. gondii on the reproductive performance of primiparous ewes in southern Australia using a prospective cohort study. This will inform the need for targeted control strategies for T. gondii in Australian sheep.

resultsToxoplasma gondii seropositivity using indirect ELISA was detected at 16/28 farms located across southern Australia. Apparent seropositivity to T. gondii was lower in primiparous ewes (1.1, 95% confidence interval (CI) 0.6, 1.8) compared to mature, multiparous ewes (8.1, 95% CI 6.0, 10.5; P < 0.001). Toxoplasma gondii seroconversion during the gestation and lambing period was confirmed for 11/1097 (1.0, 95% CI 0.5, 1.7) of pregnant primiparous ewes that failed to raise a lamb, and 1/161 (0.6, 95% CI 0.1, 2.9) primiparous ewes with confirmed mid-pregnancy abortion.

conclusionsLow frequency of detection of T. gondii seroconversion during gestation and low frequency of seropositivity to T. gondii suggests that toxoplasmosis was not an important contributor to reproductive losses in primiparous ewes on farms located over a wide geographical area in southern Australia.

Indexed as

Sheep DiseasesToxoplasmaToxoplasmosis, AnimalAbortion, VeterinaryAnimalsAntibodies, ProtozoanAustraliaFemaleHumansPregnancyProspective StudiesSheepAntibodies, ProtozoanAbortionLamb mortalityLamb survivalParasiteReproductionSheepToxoplasmosis

Identifiers

PMID35305646
PMCPMC8933891
OpenAlexW4221095316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.