Evidence map›Paper›PMID 35305614›Full record

ArticleBMC oral health2022

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study.

Julie Bartakova, Tereza Deissova, Simona Slezakova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann, Petra Borilova Linhartova, Ladislav Dušek, Lydie Izakovicova Holla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Julie Bartakova *Clinic of Stomatology, Institution Shared with St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic.
Tereza Deissova *Clinic of Stomatology, Institution Shared with St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic.
Simona SlezakovaDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 62500, Brno, Czech Republic.
Jirina BartovaDepartment of Stomatology, General University Hospital in Prague and First Faculty of Medicine, Charles University, Karlovo nam. 554/32, 12808, Prague, Czech Republic.
Jitka PetanovaInstitute of Immunology and Microbiology, General University Hospital in Prague and First Faculty of Medicine, Charles University, Karlovo nam. 554/32, Prague, Czech Republic.
Pavel KuklinekDepartment of Clinical Immunology and Allergology, Institution Shared with St. Anne's Faculty Hospital and Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic.
Antonin FassmannClinic of Stomatology, Institution Shared with St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic.
Petra Borilova LinhartovaClinic of Stomatology, Institution Shared with St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic.
Ladislav DušekInstitute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 753/5, 62500, Brno, Czech Republic.
Lydie Izakovicova HollaClinic of Stomatology, Institution Shared with St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200, Brno, Czech Republic. holla@med.muni.cz.
Masaryk University · CZCharles University · CZGeneral University Hospital in Prague · CZSt. Anne's University Hospital Brno · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population.

methodsThe study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique.

resultsThe allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P

conclusionsOur study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

Indexed as

Peptidyl-Dipeptidase AStomatitis, AphthousCase-Control StudiesCzech RepublicFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMalePolymorphism, GeneticACE protein, humanPeptidyl-Dipeptidase AAngiotensin I converting enzymeHaplotypePolymorphismRecurrent aphthous stomatitisSex difference

Identifiers

PMID35305614
PMCPMC8933959
OpenAlexW4220798444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.