Evidence map›Paper›PMID 35305612›Full record

ArticleBMC pulmonary medicine2022

A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia.

Ying-Hua Sun, Yang Du, Jie-Ru Shen, Dan-Yang Ai, Xiang-Yuan Huang, Si-Hao Diao, Sam Bill Lin, Rong Zhang, Lin Yuan, Yi-Pei Yang and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07633184 (Lung Ultrasound Score), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07633184 recruitingnot on this mapstarted 2024, after this paper: background citation

Lung Ultrasound Score (LUS) as Early Predictor of Bronchopulmonary Dysplasia (BPD) in Preterm Newborns: A Prospective, Multicenter, Observational Study

TypeobservationalSponsorAzienda USL Reggio Emilia - IRCCSRan2024 to 2027Enrolled40ConditionsBronchopulmonary DysplasiaArmsLung ultrasound at 7 (±1) days of life, Lung ultrasound at 14 (±2) days of life
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Characteristics of scores used for quantitative lung ultrasound in neonates: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Ying-Hua Sun *Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Yang Du *Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Jie-Ru Shen *Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Dan-Yang AiDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Xiang-Yuan HuangDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Si-Hao DiaoDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Sam Bill LinDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Rong ZhangDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Lin YuanDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Yi-Pei YangDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.
Li-Li HeDepartment of Ultrasound, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiao-Jiao QinDepartment of Ultrasound, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jian-Guo ZhouDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China. joezhou@fudan.edu.cn.
Chao ChenDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China. chen6010@163.com.
Children's Hospital of Fudan University · CNNational University Health System · SG

Funding

National Natural Science Foundation of China No. 81801502
6 · The paper itself

Abstract

backgroundLung ultrasound (LUS) is a useful tool for assessing the severity of lung disease, without radiation exposure. However, there is little data on the practicality of LUS in assessing the severity of bronchopulmonary dysplasia (BPD) and evaluating short-term clinical outcomes. We adapted a LUS score to evaluate BPD severity and assess the reliability of mLUS score correlated with short-term clinical outcomes.

methodsProspective diagnostic accuracy study was designed to enroll preterm infants with gestational age < 34 weeks. Lung ultrasonography was performed at 36 weeks postmenstrual age. The diagnostic and predictive values of new modified lung ultrasound (mLUS) scores based on eight standard sections were compared with classic lung ultrasound (cLUS) scores.

resultsA total of 128 infants were enrolled in this cohort, including 30 without BPD; 31 with mild BPD; 23 with moderate BPD and 44 with severe BPD. The mLUS score was significantly correlated with the short-term clinical outcomes, superior to cLUS score. The mLUS score well correlated with moderate and severe BPD (AUC = 0.813, 95% CI 0.739-0.888) and severe BPD (AUC = 0.801, 95% CI 0.728-0.875), which were superior to cLUS score. The ROC analysis of mLUS score to evaluate the other short-term outcomes also showed significant superiority to cLUS score. The optimal cutoff points for mLUS score were 14 for moderate and severe BPD and 16 for severe BPD.

conclusionsThe mLUS score correlates significantly with short-term clinical outcomes and well evaluates these outcomes in preterm infants.

Indexed as

Bronchopulmonary DysplasiaHumansInfantInfant, NewbornInfant, PrematureLungProspective StudiesReproducibility of ResultsUltrasonographyBronchopulmonary dysplasiaLung ultrasoundPremature

Identifiers

PMID35305612
PMCPMC8933905
OpenAlexW4220990414

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.