ArticleBMC musculoskeletal disorders2022
Antibiotic-loaded calcium sulfate beads in spinal surgery for patients with spondylodiscitis: a clinical retrospective study.
Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A Novel Gelatin Hydrogel-Based Drug-Delivery System Promotes Antimicrobial Efficacy in a Pyogenic Spondylodiscitis Rat Model.JOR spine · 2026Article
- Article
- Complex Aorto-Spinal Fistula With Multifocal Abscesses in an Immunosuppressed Elderly Man Following Endovascular Aortic Repair.The American journal of case reports · 2026Article
- Unilateral biportal endoscopic debridement with antibiotic-loaded cement beads implantation for lumbar spinal infection: a preliminary report on feasibility and early clinical outcomes.Frontiers in cellular and infection microbiology · 2026Article
- Proof of concept for low dose and delayed release of tigilanol tiglate in the treatment of equine sarcoids.Frontiers in veterinary science · 2026Article
- Local antibiotic carriers in the surgical management of pyogenic spondylodiscitis : First comparative evaluation of gentamicin-loaded versus vancomycin-loaded efficacy.Orthopadie (Heidelberg, Germany) · 2025Article
- In vitro mixing formulas for antimicrobial calcium sulfate beads for point-of-care applications: an additional update to formulas.Journal of bone and joint infection · 2025Article
- Vacuum assisted closure and local drug delivery systems in spinal infections: A review of current evidence.North American Spine Society journal · 2023Article
- Utilization of Antibiotic Bone Cement in Spine Surgery: Pearls, Techniques, and Case Review.Orthopedic reviews · 2023Article
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9 authors.
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Abstract
backgroundVarious surgical techniques for treating spondylodiscitis have been proposed, but the optimal surgical treatment remains controversial. In this study, we propose a new procedure that is implanting antibiotic-loaded calcium sulfate (CS) beads into the disc after debridement using the Quadrant channel combined with percutaneous fixation through a single-stage posterolateral approach for the treatment of spondylodiscitis. Thus, the purpose of this study is to assess the safety and efficacy of this procedure.
methodsThis study collected the data of 32 patients with spine spondylodiscitis and was surgically treated in our department from July 2015 to August 2020. The Demographic data included age, gender, involved segment, and complications were collected. The intra-operative details, results of culture, functional outcome, radiologic outcome, and length of hospital stay, laboratory examination were recorded.
resultsThe mean age of the 32 patients was 61.1 ± 9.7 years old. The mean operative time was 135.0 ± 30.6 minutes, and the mean blood loss was 243.4 ± 92.1 ml. The positive rate of culture was 72%. The mean Visual analogue scale (VAS) and Oswestry Disability Index (ODI) score significantly improved from 7.5 to 1.6 and from 65% to 10%. Cobb angle was significantly improved and could be maintained at final follow-up. New bone formation was observed in all patients. There were no recurrences of infection in our study.
conclusionsThe posterolateral debridement and percutaneous fixation combined with antibiotic-loaded calcium sulfate beads filling are effective in the treatment of spondylodiscitis in terms of infection control, early mobilization, and recovery.
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