Evidence map›Paper›PMID 35305601›Full record

ArticleBMC pregnancy and childbirth2022

Pre-pregnancy blood pressure and pregnancy outcomes: a nationwide population-based study.

Young Mi Jung, Gyu Chul Oh, Eunjin Noh, Hae-Young Lee, Min-Jeong Oh, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Hypertensive Disorders of Pregnancy and Primary Aldosteronism.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  4. Hypertensive Disorders of Pregnancy and Primary Aldosteronism.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Young Mi Jung *Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Gyu Chul Oh *Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Eunjin NohKorean University Guro Hospital Samrt Healthcare Center, Seongbuk-gu, Seoul, South Korea.
Hae-Young LeeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Min-Jeong OhDepartment of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, 148 Gurodong-ro, Guro-Gu, Seoul, 152-703, South Korea.
Joong Shin ParkDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Jong Kwan JunDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Seung Mi LeeDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. smleemd@hanmail.net.
Geum Joon ChoDepartment of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, 148 Gurodong-ro, Guro-Gu, Seoul, 152-703, South Korea. md_cho@hanmail.net.
Seoul National University · KRKorea University Medical Center · KRSeoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension has been known to increase the risk of obstetric complications. Recently, the American College of Cardiology endorsed lower thresholds for hypertension as systolic blood pressure of 130-139 mmHg or diastolic blood pressure 80-89 mmHg. However, there is a paucity of information regarding the impact of pre-pregnancy blood pressure on pregnancy outcomes. We aimed to evaluate the effect of pre-pregnancy blood pressure on maternal and neonatal complications.

methodsIn this nationwide, population based study, pregnant women without history of hypertension and pre-pregnancy blood pressure < 140/90 mmHg were enrolled. The primary outcome of composite morbidity was defined as any of the followings: preeclampsia, placental abruption, stillbirth, preterm birth, or low birth weight.

resultsA total of 375,305 pregnant women were included. After adjusting for covariates, the risk of composite morbidity was greater in those with stage I hypertension in comparison with the normotensive group (systolic blood pressure, odds ratio = 1.68, 95% CI: 1.59 - 1.78; diastolic blood pressure, odds ratio = 1.56, 95% CI: 1.42 - 1.72). There was a linear association between pre-pregnancy blood pressure and the primary outcome, with risk maximizing at newly defined stage I hypertension and with risk decreasing at lower blood pressure ranges.

conclusions'The lower, the better' phenomenon was still valid for both maternal and neonatal outcomes. Our results suggest that the recent changes in diagnostic thresholds for hypertension may also apply to pregnant women. Therefore, women with stage I hypertension prior to pregnancy should be carefully observed for adverse outcomes.

Indexed as

Blood PressureCohort StudiesDatabases, FactualFemaleHumansHypertensionNational Health ProgramsPregnancyPregnancy ComplicationsPregnancy Complications, CardiovascularPregnancy OutcomeRepublic of KoreaAdverse pregnancy outcomeblood pressurehypertensionpreeclampsia

Identifiers

PMID35305601
PMCPMC8934452
OpenAlexW4220808087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.