Trial reportBMC psychiatry2022
The impact of schizotypy on quality of life among adults with autism spectrum disorder.
Trial report in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03570372 (Internet-based Treatment for Adults With Autism Spectrum Disorder), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Internet-based Treatment for Adults With Autism Spectrum Disorder (MILAS)
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of Health-Related Quality of Life in Neurodivergent Children: A Systematic Review.Clinical child and family psychology review · 2024Pooled it
- Response Inhibition in Autistic Children Predicts Positive Psychotic Symptoms in Young Adulthood-Results from an 8-Year Follow-up Study.Journal of autism and developmental disorders · 2025Article
- Identifying overlapping and distinctive traits of autism and schizophrenia using machine learning classification.Cognitive neuropsychiatry · 2025Article
- Well-being and quality of life of Kenyan nurses, midwives and community health volunteers: Measurement properties and correlates of the BBQ and WHO-5.PLOS global public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) and schizotypal personality disorder can be difficult to distinguish. Deficits in social relationships and social interaction, present in both conditions, are known to impair quality of life. The aim of the present study was to investigate if schizotypal symptoms affect quality of life among adults diagnosed with autism spectrum disorder and to study the association between schizotypy and autistic traits among them.
methodsParticipants diagnosed with autism spectrum disorder (n = 110) completed questionnaires exploring schizotypy (Schizotypal Personality Questionnaire - Brief Revised (SPQ-BR)), autistic traits (The Ritvo Autism, Asperger Diagnostic Scale-Revised Screen 14 items), anxiety and depression (The Hospital Anxiety and Depression scale) and quality of life (Brunnsviken Brief Quality of Life Scale and the European quality of life index version 5D).
resultsSchizotypy was found to be associated with anxiety, depressive and autistic symptoms, and poor quality of life. Although schizotypy was a predictor for impaired quality of life, this relationship was mediated by symptoms of anxiety and depression, plausibly inherent to autism. Autistic traits were positively associated with all higher order constructs of the SPQ-BR, i.e. positive and negative schizotypy, disorganization and social anxiety, as well as with poor quality of life.
conclusionsThere is considerable overlap between schizotypy and autism that needs to be considered in research. Prominent schizotypal traits in people with ASD may constitute an endophenotype coinciding with a particularly poor quality of life.
trial registrationClinicalTrials.gov identifier: NCT03570372 : Internet-based Treatment for Adults with Autism Spectrum Disorder (MILAS).
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