ArticleCell2022
Large-scale two-photon calcium imaging in freely moving mice.
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers.
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Who cites it
198 citing papers in PubMed, 318 citations in OpenAlex.
- MIMAS: An open-source microlens-array miniature microscope for accessible large-field cortical imaging in freely behaving mice.Science advances · 2026Article
- A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small animals.Nature methods · 2026Article
- Simultaneous mesoscopic imaging of neural activity and hemodynamics reveals anesthetic modulation of neurovascular responses.Photoacoustics · 2026Article
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Miniscope Zero: a fully wireless, single-cell-resolution miniature microscope for imaging neural dynamics in freely behaving animals.bioRxiv : the preprint server for biology · 2026Article
- Drug self-administration in head-fixed mice.Nature protocols · 2026Review
- Spiral scan and cylindrical deconvolution to maximize image volume and contrast of multiphoton GRIN microendoscopy.Biomedical optics express · 2026Article
- Large-Scale Neural Recording Technologies for Investigating Circuit Dysfunction and Functional Biomarker Discovery in Animal Models of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026Review
- Simultaneous two- and three-photon multiplane imaging across cortical layers in freely moving mice.Nature methods · 2026Article
- Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice.iScience · 2026Article
- Protocol for using the multi-cellular analysis toolbox in ImageJ for single-cell calcium imaging analysis.STAR protocols · 2026Article
- CortexCAM: A Camera Array Microscope for Cortex-Wide Cellular Imaging in Freely Locomoting Mice.Research square · 2026Article
- Magnetometry for Agriculture and Animal Systems: From Classical Sensors to Quantum-Enabled Biosensing.Biosensors · 2026Review
- Multifiber Array-Based Photometry System for Multiregional Functional Mapping in the Mouse Brain.The European journal of neuroscience · 2026Article
- Article
- Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals.eLife · 2026Article
- Unsupervised transfer learning enables multi-animal tracking without training annotation.Nature methods · 2026Article
- A self-organized pencil beam that can be used for fast volumetric imaging.Nature methods · 2026Article
- Self-localized ultrafast pencil beam for volumetric multiphoton imaging.Nature methods · 2026Article
138 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution, multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a microscope weight below 3 g and a highly flexible connection cable, MINI2P allowed stable imaging with no impediment of behavior in a variety of assays compared to untethered, unimplanted animals. The improved cell yield was achieved through a optical system design featuring an enlarged field of view (FOV) and a microtunable lens with increased z-scanning range and speed that allows fast and stable imaging of multiple interleaved planes, as well as 3D functional imaging. Successive imaging across multiple, adjacent FOVs enabled recordings from more than 10,000 neurons in the same animal. Large-scale proof-of-principle data were obtained from cell populations in visual cortex, medial entorhinal cortex, and hippocampus, revealing spatial tuning of cells in all areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.