Evidence map›Paper›PMID 35305242›Full record

ReviewMolecular neurobiology2022

Improper Proteostasis: Can It Serve as Biomarkers for Neurodegenerative Diseases?

Ankur Rakesh Dubey, Som Mohanlal Patwa, Sumit Kinger, Yuvraj Anandrao Jagtap, Prashant Kumar, Sarika Singh, Rohan Dhiman, Hem Chandra Jha, Amit Mishra

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ankur Rakesh DubeyCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India, 342037.
Som Mohanlal PatwaCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India, 342037.
Sumit KingerCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India, 342037.
Yuvraj Anandrao JagtapCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India, 342037.
Prashant KumarCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India, 342037.
Sarika SinghDivision of Toxicology and Experimental Medicine, Department of Neuroscience and Ageing Biology, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Rohan DhimanLaboratory of Mycobacterial Immunology, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.
Hem Chandra JhaInfection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.
Amit MishraCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India, 342037. amit@iitj.ac.in.ORCID http://orcid.org/0000-0001-9401-4400
Indian Institute of Technology Jodhpur · INCentral Drug Research Institute · INIndian Institute of Technology Indore · INNational Institute of Technology Rourkela · IN

Funding

Board of Research in Nuclear Sciences 54/14/16/2020-BRNSScience and Engineering Research Board EMR/2016/000716
6 · The paper itself

Abstract

Cells synthesize new proteins after multiple molecular decisions. Damage of existing proteins, accumulation of abnormal proteins, and basic requirement of new proteins trigger protein quality control (PQC)-based alternative strategies to cope against proteostasis imbalance. Accumulation of misfolded proteins is linked with various neurodegenerative disorders. However, how deregulated components of this quality control system and their lack of general mechanism-based long-term changes can serve as biomarkers for neurodegeneration remains largely unexplored. Here, our article summarizes the chief findings, which may facilitate the search of novel and relevant proteostasis mechanism-based biomarkers associated with neuronal disorders. Understanding the abnormalities of PQC coupled molecules as possible biomarkers can help to determine neuronal fate and their contribution to the aetiology of several nervous system disorders.

Indexed as

Neurodegenerative DiseasesProteostasisBiomarkersHumansNeuronsProtein FoldingBiomarkersAutophagyBiomarkerChaperonesExosomesNeural diseasesNeurodegenerationProteostasisUPS

Identifiers

PMID35305242
OpenAlexW4220750931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.