Evidence map›Paper›PMID 35305172›Full record

Observational studyEuropean journal of epidemiology2022

Statin use is associated with lower risk of dementia in stroke patients: a community-based cohort study with inverse probability weighted marginal structural model analysis.

Zhirong Yang, Sengwee Toh, Xiaojuan Li, Duncan Edwards, Carol Brayne, Jonathan Mant

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
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  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zhirong YangPrimary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. zy266@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-1562-0603
Sengwee TohDepartment of Population Medicine, Harvard Medical School &, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Xiaojuan LiDepartment of Population Medicine, Harvard Medical School &, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Duncan EdwardsPrimary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Carol BrayneCambridge Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Jonathan MantPrimary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
University of Cambridge · GBHarvard University · US

Funding

Novel causal inference methods to inform clinical decision on when to discontinue symptomatic treatment for patients with dementiaR03AG070661 · NIA · HARVARD PILGRIM HEALTH CARE, INC. · PI LI, XIAOJUAN · 2021 to 2022
$332k
NIA NIH HHS R03 AG070661NIHR School for Primary Care Research reference number 340NIHR School for Primary Care Research SPCR-2014-10043
6 · The paper itself

Abstract

Current evidence is inconclusive on cognitive benefits or harms of statins among stroke patients, who have high risk of dementia. This observational cohort study investigated the association between statin use and post-stroke dementia using data from the Clinical Practice Research Datalink. Patients without prior dementia who had an incident stroke but received no statins in the preceding year were followed for up to 10 years. We used inverse probability weighted marginal structural models to estimate observational analogues of intention-to-treat (ITT, statin initiation vs. no initiation) and per-protocol (PP, sustained statin use vs. no use) effects on the risk of dementia. To explore potential impact of unmeasured confounding, we examined the risks of coronary heart disease (CHD, positive control outcome), fracture and peptic ulcer (negative control outcomes). In 18,577 statin initiators and 14,613 non-initiators (mean follow-up of 4.2 years), the adjusted hazard ratio (aHR) for dementia was 0.70 (95% confidence interval [CI] 0.64-0.75) in ITT analysis and 0.55 (95% CI 0.50-0.62) in PP analysis. The corresponding aHR

Indexed as

DementiaHydroxymethylglutaryl-CoA Reductase InhibitorsPeptic UlcerStrokeCohort StudiesHumansModels, StructuralProbabilityRetrospective StudiesHydroxymethylglutaryl-CoA Reductase InhibitorsCohort studyDementiaStatinsStroke

Identifiers

PMID35305172
PMCPMC9288375
OpenAlexW4220668415

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.