ArticlePediatric radiology2022
Doxycycline sclerotherapy of cervical spine aneurysmal bone cysts: single-institution 13-year experience.
Article in Pediatric radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Gelified ethanol for percutaneous sclerotherapy of bone lesions: a systematic review of clinical applications and outcomes.Skeletal radiology · 2026Pooled it
- Spinal aneurysmal bone cysts in children - institutional chart review and recommendation for treatment.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Minimally Invasive Treatment of Aneurysmal Bone Cysts Utilizing a Modified Sclerograft Technique.Cardiovascular and interventional radiology · 2026Article
- Aneurysmal bone cyst associated with a dentigerous cyst in the mandible: A diagnostic challenge-case report.Radiology case reports · 2026Article
- Article
- Application of unilateral biportal endoscopy in minimally invasive treatment of non-aggressive spinal benign tumors: technical note and preliminary clinical study.Frontiers in surgery · 2026Article
- Resection and 3D-printed prosthetic reconstruction of a giant aneurysmal bone cyst in the atlas: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Novel Clinical Practice Assessments: Informational Statements by the Musculoskeletal Tumor Society.Journal of surgical oncology · 2025Review
- Transoral resection of a symptomatic odontoid process aneurysmal bone cyst: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Assessment and management of periacetabular aneurysmal bone cysts-a series of four cases.Journal of hip preservation surgery · 2025Article
- Image-Guided Musculoskeletal Interventional Radiology in the Personalised Management of Musculoskeletal Tumours.Journal of personalized medicine · 2024Review
- Sclerotherapy as a Primary or Salvage Procedure For Aneurysmal Bone Cyst: A Case Report.Journal of orthopaedic case reports · 2024Article
- A New Radiological Scoring System as a Method of Assessing Sclerotherapy Treatment Response for Aneurysmal Bone Cysts: A Retrospective Study.The Indian journal of radiology & imaging · 2024Article
- Denosumab and sclerotherapy for recurrent spinal aneurysmal bone cyst in a child.BMJ case reports · 2024Article
- Minimizing neurovascular complications during image-guided percutaneous cryoablation of a cervical spinal aneurysmal bone cyst using protective doxycycline sclerotherapy: a case report.Journal of spine surgery (Hong Kong) · 2024Article
- Efficacy of Percutaneous Treatment of Primary Aneurysmal Bone Cysts (ABCs): A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts: A single-center experience.World journal of orthopedics · 2023Article
- Skull base chondroblastoma with aneurysmal bone cyst-like changes treated with percutaneous radiofrequency ablation and doxycycline sclerotherapy: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Management of aneurysmal bone cysts of the spine and sacrum: A narrative review.Journal of craniovertebral junction & spineReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAneurysmal bone cysts (ABCs) are benign, locally aggressive neoplasms that typically affect patients during their first two decades of life. Curettage with or without bone grafting or adjuvants is the current standard treatment; however, other surgical and medical treatments, such as sclerotherapy, have been reported. Treatment options for cervical spine ABCs are more limited because the proximity of ABCs to critical structures leads to greater risk of spontaneous or treatment-related adverse events, including death.
objectiveTo retrospectively review all children and young adults with cervical spine ABCs treated with doxycycline sclerotherapy at one referral center to assess its viability as a standalone treatment. MATERIALS AND
methodsWe retrospectively reviewed the clinical notes and imaging of 16 patients treated with doxycycline sclerotherapy for pathologically proven cervical spine ABCs at our institution between May 2008 and March 2021. All patients underwent image-guided percutaneous doxycycline sclerotherapy to ablate the ABC and stimulate bone formation. We assessed clinical outcomes through chart review and described post-treatment imaging outcomes using modified Neer scoring.
resultsOf the 16 total children and young adults treated, 2 were lost to follow-up, leaving 14 patients with a median age of 14.5 years. Twelve of these 14 patients were successfully treated with doxycycline sclerotherapy for a success rate of 86%. One patient experienced one treatment-related complication (Society of Interventional Radiology [SIR] adverse event classification D), before ultimately being successfully treated. Doxycycline treatment failed in two patients, who then underwent surgical management. Post-treatment imaging of successfully treated cases had a mean modified Neer score of 1.3, whereas post-treatment imaging in failed cases had a mean score of 3.5.
conclusionDoxycycline sclerotherapy is a viable standalone treatment for cervical spine ABCs because it is safe and effective while avoiding the morbidity associated with open surgical treatments.
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