Evidence map›Paper›PMID 35305105›Full record

ArticleThe oncologist2022

Use of Single-Item Self-Rated Health Measure to Identify Frailty and Geriatric Assessment-Identified Impairments Among Older Adults with Cancer.

Smith Giri, Nabiel Mir, Mustafa Al-Obaidi, Deanna Clark, Kelly M Kenzik, Andrew McDonald, Crystal Young-Smith, Ravi Paluri, Lakshmin Nandagopal, Olumide Gbolahan and 5 more

Open access · goldAbstract read
In one paragraph

Article in The oncologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Polypharmacy and the Change of Self-Rated Health in Community-Dwelling Older Adults.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Smith GiriInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.
Nabiel MirDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-0635-3985
Mustafa Al-ObaidiInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.
Deanna ClarkInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.ORCID 0000-0002-7010-4409
Kelly M KenzikInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.
Andrew McDonaldInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.
Crystal Young-SmithDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ravi PaluriDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Lakshmin NandagopalDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Olumide GbolahanDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Kirsten A NyropDivision of Oncology, The University of North Carolina at Chapel Hill, NC, USA.
Hyman B MussDivision of Oncology, The University of North Carolina at Chapel Hill, NC, USA.
Mackenzi PergolottiRevital Cancer Rehabilitation, Select Medical, Mechanicsburg, PA, USA.
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.
Grant R WilliamsInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, AL, USA.
University of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USColorado State University · US

Funding

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M StudyK08CA234225 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, GRANT R · 2018 to 2022
$1.0M
NCI NIH HHS K08 CA234225NIH HHS K08CA234225
6 · The paper itself

Abstract

backgroundPoor self-rated health (SRH) is a known predictor of frailty and mortality in the general population; however, its role among older adults with cancer is unknown. We evaluated the role of SRH as a potential screening tool to identify frailty and geriatric assessment (GA)-identified impairments. MATERIALS AND

methodsAdults ≥60 years diagnosed with cancer in the UAB Cancer & Aging Resilience Evaluation (CARE) registry underwent a GA at the time of initial consultation. We measured SRH using a single-item from the Patient-Reported Outcomes Measurement Information System global health scale and dichotomized responses as poor (poor, fair) and good (good, very good, and excellent). We evaluated the diagnostic performance of SRH in measuring frailty, and GA impairment (≥2 deficits among a set of seven GA domains). We examined the impact of SRH with survival using a Cox model adjusting for confounders, exploring the mediating role of frailty.

resultsSix hundred and three older adults with cancer were included, with a median age of 69 years. Overall, 45% (n = 274) reported poor SRH. Poor SRH demonstrated high sensitivity and specificity for identifying frailty (85% and 78%, respectively) and GA impairment (75% and 78%, respectively). In a Cox regression model, poor SRH was associated with inferior survival (HR = 2.26; 95% CI 1.60-3.18) after adjusting for confounders; frailty mediated 69% of this observed relationship.

conclusionSelf-rated health may be used as a screening tool to identify older adults with cancer with frailty and GA impairments. Poor SRH is associated with inferior survival, which is mediated by frailty.

Indexed as

FrailtyNeoplasmsAgedGeriatric AssessmentHealth StatusHumansProportional Hazards ModelsRegistriesagingfrailtygeriatric assessmentgeriatric oncologyself-rated health

Identifiers

PMID35305105
PMCPMC8842332
OpenAlexW4206081014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.