ArticleCommunications biology2022
Motivational signals disrupt metacognitive signals in the human ventromedial prefrontal cortex.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Conative inference as a mechanism of allostatic resilience: wanting to be and being to want.Cognitive, affective & behavioral neuroscience · 2026Review
- Rewards bias self-evaluations of ability.Communications psychology · 2025Article
- Neural correlates of Bayesian social belief updating in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Effective connectivity predicts distributed neural coding of perceptual decision confidence, uncertainty, and speed.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neural Correlates of Metacognition Impairment in Opioid Addiction.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.Nature communications · 2024Article
- The neural representation of metacognition in preferential decision-making.Human brain mapping · 2024Article
- Neural and computational underpinnings of biased confidence in human reinforcement learning.Nature communications · 2023Article
- Metacognition and the effect of incentive motivation in two compulsive disorders: Gambling disorder and obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
A growing body of evidence suggests that, during decision-making, BOLD signal in the ventromedial prefrontal cortex (VMPFC) correlates both with motivational variables - such as incentives and expected values - and metacognitive variables - such as confidence judgments - which reflect the subjective probability of being correct. At the behavioral level, we recently demonstrated that the value of monetary stakes bias confidence judgments, with gain (respectively loss) prospects increasing (respectively decreasing) confidence judgments, even for similar levels of difficulty and performance. If and how this value-confidence interaction is reflected in the VMPFC remains unknown. Here, we used an incentivized perceptual decision-making fMRI task that dissociates key decision-making variables, thereby allowing to test several hypotheses about the role of the VMPFC in the value-confidence interaction. While our initial analyses seemingly indicate that the VMPFC combines incentives and confidence to form an expected value signal, we falsified this conclusion with a meticulous dissection of qualitative activation patterns. Rather, our results show that strong VMPFC confidence signals observed in trials with gain prospects are disrupted in trials with no - or negative (loss) - monetary prospects. Deciphering how decision variables are represented and interact at finer scales seems necessary to better understand biased (meta)cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.