Evidence map›Paper›PMID 35304861›Full record

ArticleBiochemical pharmacology2022

(+)-Catharanthine potentiates the GABA

Hugo R Arias, Cecilia M Borghese, Allison L Germann, Spencer R Pierce, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Thanvi M Thodati, Natalie J Lim, R Adron Harris and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hugo R AriasDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, OK, USA. Electronic address: hugo.arias@okstate.edu.
Cecilia M BorgheseWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: cborghese@austin.utexas.edu.
Allison L GermannDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: germanna@wustl.edu.
Spencer R PierceDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: spencerp@wustl.edu.
Alessandro BonardiDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Florence, Italy. Electronic address: alessandro.bonardi@unifi.it.
Alessio NocentiniDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Florence, Italy. Electronic address: alessio.nocentini@unifi.it.
Paola GratteriDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Florence, Italy. Electronic address: paola.gratteri@unifi.it.
Thanvi M ThodatiWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: thanvi.thodati@utexas.edu.
Natalie J LimWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: natalie.lim@utexas.edu.
R Adron HarrisWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA. Electronic address: harris@austin.utexas.edu.
Gustav AkkDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: akk@wustl.edu.
The University of Texas at Austin · USUniversity of Florence · ITWashington University in St. Louis · USOklahoma State University Medical Center · US

Funding

Integrative Neuroscience Initiative on AlcoholismU24AA025479 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI ROBERT O. MESSING · 2017 to 2026
$5.0M
SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8M
NIAAA NIH HHS U24 AA025479NIGMS NIH HHS R01 GM108580NIGMS NIH HHS R35 GM140947
6 · The paper itself

Abstract

(+)-Catharanthine, a coronaridine congener, potentiates the γ-aminobutyric acid type A receptor (GABA

Indexed as

EtomidateNeurosteroidsBinding Sitesgamma-Aminobutyric AcidMolecular Docking SimulationReceptors, GABA-AVinca AlkaloidscatharanthineEtomidategamma-Aminobutyric AcidNeurosteroidsReceptors, GABA-AVinca Alkaloids(+)-CatharanthineCoronaridine congenersElectrophysiologyMolecular dockingMolecular dynamicsPositive allosteric modulators

Identifiers

PMID35304861
PMCPMC9178925
OpenAlexW4220843493

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.