Evidence map›Paper›PMID 35304775›Full record

ArticleClinical transplantation2022

Significant improvements, but consistent disparities in survival for African Americans after liver transplantation.

Stephanie S Keeling, Malcolm F McDonald, Adrish Anand, Greta E Handing, Lyndsey L Prather, Caroline R Christmann, Prasun K Jalal, Fasiha Kanwal, George Cholankeril, John A Goss and 1 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephanie S KeelingDepartment of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-4235-8276
Malcolm F McDonaldDepartment of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.
Adrish AnandDepartment of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.
Greta E HandingDepartment of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.
Lyndsey L PratherDepartment of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.
Caroline R ChristmannDepartment of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.
Prasun K JalalDivision of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Fasiha KanwalDivision of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
George CholankerilDivision of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
John A GossDivision of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Abbas RanaDivision of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-2979-0598

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Risk Stratification for and Early Detection of Liver CancerU01CA230997 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Jagpreet Chhatwal, Hashem B El-Serag · 2018 to 2026
$6.4M
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease OutcomesR01CA256977 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KANWAL, FASIHA, SINGAL, AMIT · 2021 to 2025
$3.0M
NCI NIH HHS R01 CA256977NCI NIH HHS U01 CA230997NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Despite improvements in survival across races in the past 20 years, African Americans have worse liver transplant outcomes after orthotopic liver transplantation (OLT). This study aims at quantifying the change in disparities between African Americans and other races in survival after OLT. We retrospectively analyzed the United Network for Organ Sharing (UNOS) database for patient data for candidates who received a liver transplant between January 1, 2007 and December 31, 2017. Multivariate Cox proportional hazards regression indicated similar decreases in mortality over time for each race with a decrease in mortality for African Americans: 2010-2012 (HR = .930), 2012-2015 (HR = .882), and 2015-2017 (HR = .883) when compared to 2007-2010. Risk of mortality for African Americans compared to Caucasians varied across the 4 eras: 2007-2010 (HR = 1.083), 2010-2012 (HR = 1.090), 2012-2015 (HR = 1.070), and 2015-2017 (HR = 1.125). While African Americans have seen increases in survival in the past decade, a similar increase in survival for other races leaves a significant survival disparity in African Americans.

Indexed as

Black or African AmericanLiver TransplantationDatabases, FactualHumansProportional Hazards ModelsRetrospective StudiesUnited StatesWhite Peoplehealth disparitiesliver transplantationoutcomesrace

Identifiers

PMID35304775
PMCPMC9310351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.