SynthesisEating and weight disorders : EWD2022
Neural correlates associated with processing food stimuli in anorexia nervosa and bulimia nervosa: an activation likelihood estimation meta-analysis of fMRI studies.
Synthesis in Eating and weight disorders : EWD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The effects of neuromodulation interventions on the eating behaviors of patients with eating disorders compared to healthy controls, sham therapies, and other therapeutic approaches: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Caloric content and industrial processing modulate the mental simulation of food concepts.Psychological research · 2026Article
- Neurobehavioral Association Between Macroscopic Network Decoupling and Reduced Eating Impulsivity: A Longitudinal fMRI Study in Bulimia Nervosa.CNS neuroscience & therapeutics · 2026Article
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Shared and disorder-specific resting-state neural activity characteristics in patients with anorexia nervosa and bulimia nervosa.Journal of eating disorders · 2026Article
- Article
- Metabolic regulation of synaptic plasticity in anorexia nervosa.Frontiers in synaptic neuroscience · 2026Review
- Article
- Cariprazine as a candidate for drug repurposing in anorexia nervosa: a mechanistic hypothesis grounded in neuroimaging evidence.Frontiers in pharmacology · 2026Article
- Multidimensional structural-functional coupling uncovers network dysregulation and predicts binge-eating severity in bulimia nervosa.BMC medicine · 2025Article
- Examining the biological causes of eating disorders to inform treatment strategies.Nature reviews. Neuroscience · 2025Review
- Article
- What the Eye Sees, the Mind Rejects: Implicit Visual Processing of Food Images in Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Emotional Eating, Impulsivity, and Affective Temperaments in a Sample of Obese Candidates for Bariatric Surgery: Which Linkage?Brain sciences · 2025Article
- Exaggerated frontoparietal control over cognitive effort-based decision-making in young women with anorexia nervosa.Molecular psychiatry · 2025Article
- Automatic engagement of limbic and prefrontal networks in response to food images reflects distinct information about food hedonics and inhibitory control.Communications biology · 2025Article
- Mapping gray matter changes in anorexia nervosa: a functional connectivity network approach.Frontiers in nutrition · 2025Article
- Anorexia Nervosa Across the Lifespan: A Review of Recent Literature.Focus (American Psychiatric Publishing) · 2024Review
- Emotional food-cue-reactivity in anorexia nervosa and bulimia nervosa: An electroencephalography study.The International journal of eating disorders · 2023Article
- Neural effects of deep brain stimulation on reward and loss anticipation and food viewing in anorexia nervosa: a pilot study.Journal of eating disorders · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVarious neurobiological models have utilised symptom categories to explore the underlying neural correlates in both anorexia nervosa (AN) and bulimia nervosa (BN). The aim of this research was to investigate the brain activity patterns associated with viewing food stimuli in anorexia nervosa and bulimia nervosa.
methodsElectronic databases including PsycInfo and PubMed were systematically searched from data base inception until 1st of December 2020, identifying 14 suitable functional magnetic resonance imaging studies (fMRI), involving 470 participants. ALE meta-analysis was used to statistically analyse the overlap of activation foci from different fMRI studies in response to visual food stimuli.
resultsComparing patients with AN with healthy control (HC), we detected hypoactivation in brain areas related to reward processing (i.e., amygdala and lentiform nucleus), and interoceptive processing (i.e., insula). In addition, patients with AN showed hyperactivations in cognitive control areas (i.e., prefrontal and anterior cingulate cortex). In contrast, patients with BN exhibited hyperactivations in brain areas related to reward processing (i.e., lentiform nucleus), and interoceptive processing (i.e., insula). Furthermore, patients with BN showed hypoactivations in brain regions associated with cognitive control (i.e., prefrontal and anterior cingulate cortex).
conclusionsOur study shows differing neural endotypes of the two types of eating disorders, that underpin their behavioural phenotypes. While exploratory in nature, these findings might be relevant for guiding new emerging therapies, including invasive and non-invasive neuromodulation techniques in treatment of eating disorders. LEVEL OF EVIDENCE: Level I, meta-analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.