Evidence map›Paper›PMID 35304704›Full record

Observational studyAging clinical and experimental research2022

Prevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial.

Alenka Stahl-Gugger, Caroline de Godoi Rezende Costa Molino, Maud Wieczorek, Patricia O Chocano-Bedoya, Lauren A Abderhalden, Dominik J Schaer, Donat R Spahn, E John Orav, Bruno Vellas, José A P da Silva and 4 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  19. Could iron deficiency potentiate the appearance of complications in Influenza A virus infection?Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Alenka Stahl-Gugger *Center on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Caroline de Godoi Rezende Costa Molino *Center on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Maud WieczorekCenter on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Patricia O Chocano-BedoyaCenter on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Lauren A AbderhaldenCenter on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Dominik J SchaerClinic for Internal Medicine, University Hospital Zurich, Zurich, Switzerland.
Donat R SpahnInstitute of Anesthesiology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
E John OravDepartment of Biostatistics, Harvard School of Public Health, Boston, USA.
Bruno VellasGérontopôle de Toulouse, Institut du Vieillissement, Center Hospitalo-Universitaire de Toulouse, Toulouse, France.
José A P da SilvaInstitute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Reto W KressigUniversity Department of Geriatric Medicine FELIX PLATTER, and University of Basel, Basel, Switzerland.
Andreas EgliCenter on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Heike A Bischoff-FerrariCenter on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland. Heike.Bischoff@usz.ch.ORCID http://orcid.org/0000-0002-4554-658X
DO-HEALTH Research Group
Group Health Cooperative · USUniversity of Zurich · CHHarvard University · USHospitais da Universidade de Coimbra · PTUniversité Toulouse III - Paul Sabatier · FRUniversity of Basel · CHUniversity Hospital of Zurich · CHUniversity of Bern · CH

Funding

European Commission EC-GA № 278588University of Zurich Aging ResearchUniversity of Zurich Chair for Geriatric MedicineVifor Pharma independentVifor Pharma investigator-initiated grant
6 · The paper itself

Abstract

BACKGROUND AND

aimIron deficiency is associated with increased morbidity and mortality in older adults. However, data on its prevalence and incidence among older adults is limited. The aim of this study was to investigate the prevalence and incidence of iron deficiency in European community-dwelling older adults aged ≥ 70 years.

methodsSecondary analysis of the DO-HEALTH trial, a 3-year clinical trial including 2157 community-dwelling adults aged ≥ 70 years from Austria, France, Germany, Portugal and Switzerland. Iron deficiency was defined as soluble transferrin receptor (sTfR) > 28.1 nmol/L. Prevalence and incidence rate (IR) of iron deficiency per 100 person-years were examined overall and stratified by sex, age group, and country. Sensitivity analysis for three commonly used definitions of iron deficiency (ferritin < 45 μg/L, ferritin < 30 μg/L, and sTfR-ferritin index > 1.5) were also performed.

resultsOut of 2157 participants, 2141 had sTfR measured at baseline (mean age 74.9 years; 61.5% women). The prevalence of iron deficiency at baseline was 26.8%, and did not differ by sex, but by age (35.6% in age group ≥ 80, 29.3% in age group 75-79, 23.2% in age group 70-74); P < 0.0001) and country (P = 0.02), with the highest prevalence in Portugal (34.5%) and the lowest in France (24.4%). As for the other definitions of iron deficiency, the prevalence ranged from 4.2% for ferritin < 30 µg/L to 35.3% for sTfR-ferritin index > 1.5. Occurrences of iron deficiency were observed with IR per 100 person-years of 9.2 (95% CI 8.3-10.1) and did not significantly differ by sex or age group. The highest IR per 100 person-years was observed in Austria (20.8, 95% CI 16.1-26.9), the lowest in Germany (6.1, 95% CI 4.7-8.0). Regarding the other definitions of iron deficiency, the IR per 100 person-years was 4.5 (95% CI 4.0-4.9) for ferritin < 45 µg/L, 2.4 (95% CI 2.2-2.7) for ferritin < 30 µg/L, and 12.2 (95% CI 11.0-13.5) for sTfR-ferritin index > 1.5.

conclusionsIron deficiency is frequent among relatively healthy European older adults, with people aged ≥ 80 years and residence in Austria and Portugal associated with the highest risk.

Indexed as

Anemia, Iron-DeficiencyIron DeficienciesAgedFemaleFerritinsHumansIncidenceIndependent LivingMalePrevalenceReceptors, TransferrinFerritinsReceptors, TransferrinCommunity-dwelling older adultsEuropeIncidenceIron deficiencyPrevalence

Identifiers

PMID35304704
PMCPMC9464157
OpenAlexW4221020639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.